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| Title | Prefrontal-limbic change in dopamine turnover by acupuncture in maternally separated rat pups. |
|---|---|
| Authors | Kwon S, Kim D, Park H, Yoo D, Park HJ, Hahm DH, Lee H, Kim ST. |
| Journal | Neurochem Res. |
| Year | 2012 |
| Vol (Issue) | 37(10) |
| Page | 2092-8. |
| doi | 10.1007/s11064-012-0830-1. |
| PMID | |
| Url | |
| MeSH | Acupuncture* |
| Keywords | Acupuncture; HT7; Maternal separation; Depression; Dopamine; Corticosterone |
| 한글 키워드 | 침 치료; 신문; 산모 격리; 우울증; 도파민; 코르티코스테론 |
| KMCRIC Summary & Commentary |
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| Korean Study | Y |
| Abstract | The present study investigated the possible role of acupuncture in alleviating depression-like behavioral changes and examined changes in the levels of serotonin (5-HT), dopamine (DA), and their metabolites in the hippocampus (HP) and prefrontal cortex (PFC) of maternally separated rat pups. On postnatal day 15, rat pups were maternally separated and received acupuncture stimulation at acupoint HT7 or ST36 once a day for 7 days. Then, on postnatal day 21, a tail suspension test was performed, and the HP and PFC were harvested. Levels of 5-HT, 5-hydroxyindole-3-acetic acid (5-HIAA), DA, and 3,4-dihydroxyphenylacetic acid (DOPAC) in the tissue were then measured by high-performance liquid chromatography analysis. The total duration of immobility in maternally separated rat pups increased after maternal separation, and this increase was alleviated by acupuncture stimulation at HT7. The 5-HIAA/5-HT ratio and the levels of 5-HT and 5-HIAA were not significantly changed, but those of DA and the DOPAC/DA ratio were significantly lower after maternal separation. The maternal separation–induced reduction of the DOPAC/DA ratio significantly improved after acupuncture stimulation at HT7. |
| 국문초록 | |
| Language | 영어 |
| 첨부파일 |