KMCRIC

중풍 후 우울증에 대한 반하후박탕의 유효성 및 적응증 평가.

나병조, 정재한, 최창민, 홍진우, 김태훈, 이준우, 이차로, 반건호, 정우상, 문상관, 배형섭.

대한한방내과학회지.

2005

26(3)

563-574.

Banhahubak-tang(Banxiahoupotang); poststroke depression; BDI

반하후박탕; 뇌졸중 후 우울증; 벡 우울 척도

없음

Y

Objectives : Poststroke depression is a frequent and specific entity that impaires the rehabilliation and functional recovery of patients with hcmiplegia. The author evaluated the effect of Banhahubak-tang(Banxiahoupotang) in patients with poststroke depression. Methods : 38 patients suffering from poststroke depression(determined by Diagnostic and Statistical Manual of Mental Disorders, revised. 3rd edition. and Beck Depression Inventory[BDI] cutoff point≥10) in Kyunghee Oriental hospital were randomized into two groups; treatment group(n=19) and control group(n=19). The treatment group was prescribed with Banhahubak-tang(Banxiahoupotang) three times a day for a week. Control group was prescribed with other herbal medicines used for stroke patients three times a day for a week. Patients were evaluated by use of BDI scale, Modified Barthel Index, Depression of Ki score, Yin syndrome score, and Yang syndrome score. Among 38 patients, 24 patients got BDI scores above 21, which is the cut-off score for depression in Korean. The same procedures and assessments described above were applied. Results : Treatment group did not significantly improve compared with control group. Results yielded only slight significance (P=0.086). Especially. patients with poststroke depression as yin syndrome improved more significantly on BDI than those classified as yang syndrome. When BDI cutoff point for depression was defined as being ≥ 21, treatment group did not significantly improve compared with control group(P=0.114). However, patients with poststroke depression classified as yin syndrome were also significantly improved on BDI than those classified as yang syndrome. Conclusions : This study suggests that Banhahubak-tang(Banxiahoupotang) is significantly effective in patients with poststroke depression classified as yin syndrome.

1. BDI 10점 이상으로 경증이상의 중풍후우울증 환자를 대상으로 하였을 때 半夏厚朴湯투여군은 대조군(타처방투여군)에 비해 유의한 결과를 보이지 않았다(P＝0.086). 2. BDI 21점 이상인 중풍후우울증 환자를 대상으로 하였을 때 半夏厚朴湯 투여군은 대조군(타처방투여군)에 비해 유의한 결과를 보이지 않았다(P＝0.114). 3. BDI 10점 이상인 경증이상의 중풍후우울증 환자를 대상으로 하였을 때와 BDI 21점 이상인 중풍후우울증 환자를 대상으로 하였을 때 모두 陰證(寒證)으로 변증한 중풍후우울증 환자가 陽證(熱證)으로 변증한 환자보다 유의한 결과를 보였다(P＜0.05). 4. BDI 10점 이상인 경증이상의 중풍후우울증 환자를 대상으로 하였을 때와 BDI 21점 이상인 중풍후우울증 환자를 대상으로 하였을 때 MBI와 氣鬱 점수상 半夏厚朴湯 투여군과 대조군(타처방투여군)은 유의한 차이를 보이지 않았다. 결론적으로 半夏厚朴湯은 중풍후우울증 환자중 특히 陰證(寒證)으로 변증한 중풍후우울증 환자에게 효과가 있는 것으로 사료된다.

한국어