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근거중심한의약 DB
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| Title | Anti-hypertensive Effect of Chunghyul-dan(Qingxue-dan) on Stroke Patients with Essential Hypertension. |
|---|---|
| Authors | Yun SP, Jung WS, Park SU, Moon SK, Ko CN, Cho KH, Kim YS, Bae HS. |
| Journal | Am J Chin Med. |
| Year | 2005 |
| Vol (Issue) | 33(3) |
| Page | 357-364. |
| doi | 10.1142/S0192415X05002977 |
| PMID | |
| Url | |
| MeSH | Aged |
| Keywords | Hypertension; Stroke; Chunghyul-dan; Scutellariae Radix; Coptidis Rhizoma; Phellodendri Cortex; TPR; SI |
| 한글 키워드 | 고혈압; 뇌졸중; 청혈단; 황금; 황련; 황백; 전신 반응 교수법; 평활도 지수 |
| KMCRIC summary and commentary | 없음 |
| Korean Study | Y |
| Abstract | Hypertension is one of the modifiable risk factors for stroke. Lowering blood pressure is helpful for primary and secondary prevention of stroke. This study is aimed to assess the efficacy of Chunghyul-dan on stroke patients with stage 1 hypertension using 24 hours ambulatory blood pressure monitoring (24ABPM). Forty hospitalized stroke patients with stage 1 hypertension were included in the study and they were randomly assigned into two groups: group A was treated with Chunghyul-dan 1200 mg once a day for 2 weeks, while group B was not. Twelve subjects were dropped out because of unexpected early discharge or data errors, thus the remaining 28 subjects were included in the final analysis (15 in group A and 13 in group B). Blood pressure was monitored every 30 minutes for 24 hours at baseline and 2 weeks after medication. Blood pressure, pulse rate, trough/peak ratio (TPR) [the value calculated by dividing the blood pressure change at trough (22 to 24 hours after drug intake) by the change at peak (2 adjacent hours with a maximal blood pressure reduction between the second and eighth hour after drug intake)] and smoothness index (SI) (the value calculated as the ratio between the average of the 24 hours, treatment-induced blood pressure changes and its standard deviation) were compared to assess the efficacy of Chunghyul-dan. To assess the safety of Chunghyul-dan, any adverse effects during medication period were monitored. There was no significant difference in the baseline assessment between the two groups. Systolic blood pressure was lower in group A than in group B (141.37+/-8.96 mmHg versus 132.28+/-9.46 mmHg, P = 0.03), while diastolic blood pressure and pulse rate had no significant difference between the two groups. Systolic TPR and SI was 0.87 and 1.04 in group A, respectively. This suggests that Chunghyul-dan have anti-hypertensive effect on stroke patients with stage 1 hypertension. |
| 국문초록 | |
| Language | 영어 |
| 첨부파일 |