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Title

Analysis of clinical evaluation of response to treatment of Parkinson's disease with integrated Chinese and Western medicine therapy.

Authors

Li M, Yang MH, Liu Y, Luo XD, Chen JZ, Shi HJ.

Journal

Chin J Integr Med.

Year

2014

Vol (Issue)

21(1)

Page

17-21.

doi

10.1007/s11655-014-1760-3.

PMID

24916808

Url

http://www.ncbi.nlm.nih.gov/pubmed/24916808

MeSH

Aged
Aged, 80 and over
Female
Humans
Integrative Medicine*
Male
Medicine, Chinese Traditional*/adverse effects
Middle Aged
Parkinson Disease/physiopathology
Parkinson Disease/therapy*
Sleep
Time Factors
Treatment Outcome

Keywords

Parkinson’s disease; integrated Chinese and Western medicine therapy; means of clinical evaluation

한글 키워드

파킨슨 병; 중서의 통합치료; 임상적 평가의 평균

KMCRIC
Summary & Commentary

KMCRIC 비평 보기 +

Korean Study

Abstract

OBJECTIVE:
To analyze the clinical evaluation of Parkinson's disease (PD) patients receiving integrated Chinese and Western medicine therapy.

METHODS:
One hundred and twenty patients were enrolled and randomly allocated to a control group or treatment group. Patients in the two groups received placebo and Bushen Huoxue Granule (, BHG), respectively. Both groups received baseline levodopa and benserazide (Madopar). The effects of treatment were assessed monthly during the 9-month treatment. Means of evaluation included Unified PD Rating Scale (UPDRS) scores (II and III), sleep scale score, 10 m turn back test (getting up time, 10 m×2 times, and turning time), timing motor test (TMT)-left and TMT-right, which were treated as the dependent variables; and age, sex, duration of PD, Hoehn and Yahr (H-Y) stage and Madopar dosage of admitted PD patients were as the independent variables. Multiple linear regression was used to analyze these factors.

RESULTS:
H-Y stage significantly affected UPDRS II score, UPDRS III score, and getting up time (P <0.01). Madopar dosage and H-Y stage significantly affected the 10 m×2 times (P <0.05 or P <0.01). Madopar dosage significantly affected the sleep scale score (P <0.05). There were also significant correlations between age and TMT-left or TMT-right (P <0.01), and duration of PD and TMT-right (P <0.05).

CONCLUSIONS:
The six assessed means of clinical evaluation (including UPDRS II and UPDRS III scores, sleep scale score, getting up time, 10 m×2 times, and turning time) are sensitive indexes in all PD patients. H-Y stage and Madopar dosage are the major factors influencing means of clinical assessment of PD treatment.

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