KMCRIC

Effect of rhubarb (Rheum emodi) in primary dysmenorrhoea: a single-blind randomized controlled trial.

Rehman H, Begum W, Anjum F, Tabasum H, Zahid S.

J Complement Integr Med.

2015

12(1)

61-9.

10.1515/jcim-2014-0004.

25367691

http://www.ncbi.nlm.nih.gov/pubmed/25367691

Adolescent
Adult
Dysmenorrhea/complications
Dysmenorrhea/drug therapy*
Female
Humans
Pain/drug therapy*
Pain/etiology
Pain Measurement
Phytotherapy*
Plant Extracts/pharmacology
Plant Extracts/therapeutic use*
Quality of Life*
Rheum*
Single-Blind Method
Young Adult

anti-inflammatory; mefenamic acid; primary dysmenorrhoea; prostaglandins; Rheum emodi

항염증; 메페남산; 원발성 월경곤란증; 프로스타글란딘; 대황

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Background: The aim of this study was to investigate and evaluate the efficacy of Rheum emodi in the management of primary dysmenorrhoea. Methods: A randomized, single-blind, standard controlled trial compared efficacy of R. emodi against mefenamic acid on diagnosed subjects of primary dysmenorrhoea for three consecutive cycles. Experimental group (n=30) received capsules of R. emodi powder two times a day, two days before the expected date of menstruation, and continued first three days of menstruation, while control group (n=15) participants received mefenamic acid capsules three times a day on the same protocol. The primary outcome measures were reduced in severity and duration of pain, assessed by visual analogue scale (VAS) and verbal multidimensional scoring system (VMSS), and secondary outcome measures were overall improvement of dysmenorrhoea and improved in quality of life (QOL). Statistical analysis was done by repeated measures analysis of variance and Chi-square/Fisher Exact test. Results: The menstrual pain was significantly decreased in both groups after three-cycle intervention. Significant changes were observed in VAS (p<0.001) and VMSS (p<0.001) in the experimental group. There is a significant (p<0.001) reduction in duration of pain in both the groups. Associated symptoms and QOL were markedly improved after treatment (p<0.001). Conclusions: It has been clear from the above result that R. emodi is an effective herb in alleviating symptoms of primary dysmenorrhoea. It can serve as an alternative treatment without any apparent side effects. These results deserve further investigations.

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