KMCRIC

Chinese Herbal Medicine for Obesity: A Randomized, Double-Blinded, Multicenter, Prospective Trial.

Zhou Q, Chang B, Chen XY, Zhou SP, Zhen Z, Zhang LL, Sun X, Zhou Y, Xie WQ, Liu HF, Xu Y, Kong Y, Zhou LB, Lian FM, Tong XL.

Am J Chin Med.

2014

42(6)

1345-56

10.1142/S0192415X14500840.

25406653

http://www.ncbi.nlm.nih.gov/pubmed/25406653

Adolescent
Adult
Body Mass Index
Body Weight
Cassia
Citrus
Coptis
Dose-Response Relationship, Drug
Double-Blind Method
Drugs, Chinese Herbal/administration & dosage*
Female
Humans
Insulin Resistance
Male
Middle Aged
Obesity/drug therapy*
Obesity/physiopathology
Peptides, Cyclic
Prospective Studies
Rheum
Time Factors
Treatment Outcome
Waist Circumference
Young Adult

Body Weight Control; Chinese Medicine; Citrus aurantium; Clinical Trial; Coptis; Semen cassia; Obesity; Overweight; Rhubarb; Xin-Ju-Xiao-Gao-Fang

체중 조절; 중의학; 광귤나무; 임상 시험; 황련; 결명자; 비만; 과체중; 대황; 대황, 황련, 결명자, 지실로 구성된 처방

KMCRIC 비평 보기 +

Obesity is a serious medical problem worldwide. As a holistic therapy, traditional Chinese medicine (TCM) may have a potential in obesity management. In this controlled trial, we evaluated the safety and effectiveness of Xin-Ju-Xiao-Gao-Fang (XJXGF), a TCM herbal formulation, in 140 obese subjects over a 24-week period. The XJXGF formula mainly consists of rhubarb, coptis, semen cassia, and citrus aurantium. Subjects with body mass index (BMI) 28-40 kg/m(2) were recruited at 5 centers in China. We assessed the changes in subjects' body weight, its related parameters, and the reduction of insulin resistance (IR) after administration of XJXGF formula or low-dose XJXGF (10% of the XJXGF formula, as control). After 24-week treatment, among participants in the XJXGF formula group and low-dose XJXGF group, the mean ± SE changes in the body weight were -3.58 ± 0.48 and -1.91 ± 0.38 kg, respectively (p < 0.01). The changes in the IR-index of two groups were -2.65 ± 1.04 and -1.58 ± 1.3, respectively (p < 0 .05). There were no serious adverse events reported during the 24-week trial. Participants reported 7 minor adverse events, 4 in the XJXGF formula group and 3 in the low-dose XJXGF group (p = 0.578). Future studies are needed to investigate the clinical utility of this TCM formulation in the treatment of obese subjects.

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