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Practical Application of Antidiabetic Efficacy of Lycium barbarum Polysaccharide in Patients with Type 2 Diabetes.

Cai H, Liu F, Zuo P, Huang G, Song Z, Wang T, Lu H, Guo F, Han C, Sun G.

Med Chem.

2014

25381995

http://www.ncbi.nlm.nih.gov/pubmed/25381995

Aged
Blood Glucose/metabolism
Diabetes Mellitus, Type 2/blood
Diabetes Mellitus, Type 2/drug therapy*
Diabetes Mellitus, Type 2/physiopathology
Double-Blind Method
Drug Administration Schedule
Drugs, Chinese Herbal/chemistry*
Drugs, Chinese Herbal/isolation & purification
Drugs, Chinese Herbal/therapeutic use
Female
Humans
Hypoglycemic Agents/isolation & purification
Hypoglycemic Agents/therapeutic use*
Insulin/agonists
Insulin/blood
Lipoproteins, HDL/agonists
Lipoproteins, HDL/blood
Lycium/chemistry*
Male
Middle Aged
Prospective Studies
Treatment Outcome

Lycium barbarum polysaccharide; type 2 diabetes; glucose; lipids; cytokines

영하구기자 다당류; 제 2형 당뇨병; 글루코스; 지질; 사이토카인

없음

Lycium barbarum polysaccharide (LBP) has been traditionally used in Chinese medicine as a chief ingredient of L. barbarum (wolf berry/goji berry) for the treatment of various diseases with the symptom of frequent drinking and urination. The study was a randomized, controlled clinical trial. A total of 67 patients with type 2 diabetes (30 in control group and 37 in LBP group) participated in this prospective, randomized, double-blind study (administration at 300mg/day body weight). In order to observe the hypoglycemic and lipid-lowering activity of LBP in patients with type 2 diabetes after dinner, varieties were tested between control and LBP intervention groups in 3 months. Although, the study had small sample size and short follow-up, significant findings were got. The results of our study indicated a remarkable protective effect of LBP in patients with type 2 diabetes. Serum glucose decreased significantly and insulinogenic index increased during OMTT after 3 months administration by LBP. LBP also increased HDL levels in patients with type 2 diabetes. It had more obvious hypoglycemic efficacy for those people who did not take any hypoglycemic medicine compared to patients with hypoglycemic medicines. This study showed that LBP should be a good potential treatment aided-agent for type 2 diabetes.

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