| Title |
Does inchinkoto, a herbal medicine, have hepatoprotective effects in major hepatectomy? A prospective randomized study. |
| Authors |
Mizutani T, Yokoyama Y, Kokuryo T, Ebata T, Igami T, Sugawara G, Nagino M. |
| Journal |
HPB (Oxford). |
| Year |
2015 |
| Vol (Issue) |
17(5) |
| Page |
461-9. |
| doi |
10.1111/hpb.12384. |
| PMID |
25581163 |
| Url |
http://www.ncbi.nlm.nih.gov/pubmed/25581163 |
| MeSH |
3',5'-Cyclic-AMP Phosphodiesterases/antagonists & inhibitors
Aged
Drugs, Chinese Herbal/therapeutic use*
Female
Hepatectomy*
Humans
Liver Diseases/drug therapy*
Liver Diseases/surgery
Male
Phytotherapy/methods*
Postoperative Complications/prevention & control*
Preoperative Care/methods*
Prospective Studies |
| Keywords |
|
| 한글 키워드 |
|
KMCRIC
Summary & Commentary |
KMCRIC 비평 보기 + |
| Korean Study |
|
| Abstract |
OBJECTIVES:
This randomized clinical trial was designed to investigate whether inchinkoto has a hepatoprotective effect on postoperative outcome after major hepatectomy.
METHODS:
Sixty-one patients scheduled for major hepatectomy were randomly assigned to one of two groups in which preoperative inchinkoto was (inchinkoto group, n = 30) or was not (non-inchinkoto group, n = 31) administered. Inchinkoto was administered for at least 7 days before surgery. The primary endpoint was the incidence of post-hepatectomy liver damage. The expression of nuclear factor E2-related factor 2 (Nrf2) and other oxygen stress-related markers in the liver were also determined.
RESULTS:
There was no significant difference in clinical characteristics between the inchinkoto and non-inchinkoto groups. Serum levels in liver function tests and incidences of post-hepatectomy liver failure did not differ significantly between the two groups. However, there was a significantly higher induction of antioxidant factors in the liver, such as Nrf2 protein and heme oxygenase-1 mRNA, after hepatectomy in the inchinkoto group than in the non-inchinkoto group.
CONCLUSIONS:
The preoperative administration of inchinkoto did not have a significant impact on the overall outcome of major hepatectomy. However, inchinkoto induced the expression of Nrf2 during hepatectomy and may have exerted an antioxidative effect on the liver. |
| 국문초록 |
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| Language |
영어 |
| 첨부파일 |
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