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The effect of Sailuotong (SLT) on neurocognitive and cardiovascular function in healthy adults: a randomised, double-blind, placebo controlled crossover pilot trial.

Steiner GZ, Yeung A, Liu JX, Camfield DA, Blasio FM, Pipingas A, Scholey AB, Stough C, Chang DH.

BMC Complement Altern Med.

2016

16

15.

10.1186/s12906-016-0989-0.

26762282

http://www.ncbi.nlm.nih.gov/pubmed/26762282

Adult
Blood Pressure/drug effects*
Cognition/drug effects*
Crocus*
Cross-Over Studies
Double-Blind Method
Drug Combinations
Female
Ginkgo biloba*
Heart Rate/drug effects*
Humans
Male
Middle Aged
Panax*
Pilot Projects
Plants, Medicinal

Sailuotong (SLT); Chinese Herbal Medicine (CHM); EEG; Event-related potentials (ERPs); P3(00); Blood pressure; Heartrate (HR); Neurocognition; Age related cognitive decline

塞络通; 중약학 (CHM); 뇌전도; 사건 유발 전위 (ERPs); P3 진폭; 혈압; 심박수 (HR); 신경인지; 노화로 인한 인지 저하

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BACKGROUND:
Sailuotong (SLT) is a standardised herbal medicine formula consisting of Panax ginseng, Ginkgo biloba, and Crocus sativus, and has been designed to enhance cognitive and cardiovascular function.

METHODS:
Using a randomised, double-blind, placebo controlled crossover design, this pilot study assessed the effect of treatment for 1 week with SLT and placebo (1 week washout period) on neurocognitive and cardiovascular function in healthy adults. Sixteen adults completed a computerised neuropsychological test battery (Compass), and had their electroencephalographic (EEG) activity and cardiovascular system function assessed. Primary outcome measures were cognitive test scores and oddball task event-related potential (ERP) component amplitudes. Secondary outcome measures were resting EEG spectral band amplitudes, and cardiovascular parameters.

RESULTS:
Treatment with SLT, compared to placebo, resulted in small improvements in working memory, a slight increase in auditory target (cf. nontarget) P3a amplitude, and a decrease in auditory N1 target (cf. nontarget) amplitude. There was no effect of SLT on EEG amplitude in delta, theta, alpha, or beta bands in both eyes open and eyes closed resting conditions, or on aortic and peripheral pulse pressure, and resting heartrate.

CONCLUSIONS:
Findings suggest that SLT has the potential to improve working memory performance in healthy adults; a larger sample size is needed to confirm this.

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