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Efficacy and safety of a novel water-soluble herbal patch for acne vulgaris treatment: A randomized, assessor-blinds controlled, intra-individual split-face comparative study.

Jaturapisanukul K, Udompataikul M, Kanolrungsee S, Rojhirunsakool S, Kamanamool N, Rachpirom M, Puttarak P.

Dermatol Ther.

2021

Online ahead of print.

e14925.

10.1111/dth.14925.

33651470

http://www.ncbi.nlm.nih.gov/pubmed/33651470

acne vulgaris; herbal acne patch; hydrocolloid patch; inflammation; treatment

심상성 여드름; 허브 여드름 패치; 하이드로콜로이드 패치; 염증; 치료

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Acne vulgaris is a chronic inflammatory skin disease. Antibiotics, particularly clindamycin and erythromycin, are used for the treatment of acne vulgaris. However, emerging antibiotic-resistant strains have been an important problem. This study aims to evaluate the efficiency and safety of a novel water-soluble herbal acne patch (WHAP) compared with the hydrocolloid acne patch (HAP) in mild to moderate inflammatory acne patients. The randomized, assessor-blind controlled, intra-individual split-face study was performed on 49 acne patients. The clinical outcomes were evaluated on day 2, 4, 7, 9, and 11 of treatment. It was shown that the median time to resolution of the inflammatory acne treated with WHAP was shorter than HAP with a statistically significant difference (WHAP was 4 days, whereas HAP was 6 days) (P value <.001). Moreover, WHAP had a more significant decrease in the rate of inflammatory diameter, erythema scores (by clinical and colorimetry), and a more increase in the rate of lightness scores (by colorimetry) than HAP (P value <.05). No adverse effects were reported in both groups. It is safe to use WHAP as an alternative treatment for inflammatory acne.

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