KMCRIC

Effect of Cornus mas L. fruit extract on lipid accumulation product and cardiovascular indices in patients with non-alcoholic fatty liver disease: A double-blind randomized controlled trial.

Sangouni AA, Sangsefidi ZS, Yarhosseini F, Hosseinzadeh M, Akhondi-Meybodi M, Ranjbar A, Madadizadeh F, Mozaffari-Khosravi H.

Clin Nutr ESPEN.

2022

47

51-7.

10.1016/j.clnesp.2021.11.023.

35063242

http://www.ncbi.nlm.nih.gov/pubmed/35063242

Cornus*
Fruit
Humans
Iran
Lipid Accumulation Product*
Non-alcoholic Fatty Liver Disease* / drug therapy
Plant Extracts / pharmacology
Plant Extracts / therapeutic use

Atherogenic; Cardiovascular; Cornus mas L.; Lipid accumulation product; Non-alcoholic fatty liver disease

없음

Background & aims: Non-alcoholic fatty liver disease (NAFLD) is associated with high risk of cardiovascular diseases. The experimental studies have suggested that Cornus mas L. (cornelian cherry) fruit can improve cardiovascular risk factors. We designed a study to investigate the effect of cornelian cherry fruit extract on cardiovascular outcomes in patients with NAFLD.

Methods: We conducted a double-blind, randomized controlled trial. Fifty patients with NAFLD were randomly assigned into the treatment and the control groups. The treatment group received 20 cc/d cornelian cherry fruit extract as liquid form and the control group received 20 cc/d placebo for 12 weeks. The primary outcomes included lipid accumulation product (LAP), atherogenic index of plasma (AIP), Castelli risk index I (CRI-I), CRI-II and atherogenic coefficient (AC).

Results: At the baseline, there was no significant difference between two groups in values of LAP, AIP, CRI-I, CRI-II and AC. After the intervention, no significant change was found in the treatment group compared to the control group in LAP (-0.64 (-6.25 to 8.29) vs. 0.0 (-8.66 to 19.01); P = 0.91), AIP (0.0 ± 0.08 vs. 0.0 ± 0.1; P = 0.84), CRI-I (-0.18 ± 0.63 vs. -0.31 ± 0.49; P = 0.42), CRI-II (-0.23 ± 0.56 vs. -0.15 ± 0.32; P = 0.52) and AC (-0.18 ± 0.63 vs. -0.31 ± 0.49; P = 0.42).

Conclusion: Cornelian cherry fruit extract has no effect on cardiovascular outcomes. Further studies with longer intervention durations are needed.

Trial registration: Registered on 30 September 2018 at Iranian Registry of Clinical Trials (IRCT20180419039359N1).

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