KMCRIC

Green tea and lung cancer: a systematic review.

Fritz H, Seely D, Kennedy DA, Fernandes R, Cooley K, Fergusson D.

Integr Cancer Ther.

2013

12(1)

7-24.

10.1177/1534735412442378.

22532034

http://www.ncbi.nlm.nih.gov/pubmed/22532034

Animals
Antineoplastic Agents/pharmacology
Boronic Acids/pharmacology
Bortezomib
DNA Damage/drug effects
Herb-Drug Interactions
Humans
Lung Neoplasms/drug therapy*
Lung Neoplasms/pathology
Lung Neoplasms/prevention & control
Maximum Tolerated Dose
Phytotherapy/adverse effects
Phytotherapy/methods
Plant Extracts/administration & dosage
Plant Extracts/adverse effects
Plant Extracts/pharmacology*
Pyrazines/pharmacology
Tea*

Camellia sinensis; cancer; catechins; chemoprevention; complementary and alternative medicine; epigallocatechin gallate; green tea; herb-drug interactions; lung cancer; natural health products; systematic review

차나무; 암; 카테킨류; 화학예방요법; 보완대체의학; 에피갈로카테킨 갈레이트; 녹차; 한약-양약 상호작용; 폐암; 천연 건강 기능 식품; 체계적 문헌고찰

없음

BACKGROUND:
Green tea is a beverage widely used by lung cancer patients and the public for its purported anticancer properties. The authors conducted a systematic review of green tea for the treatment and prevention of lung cancer.

METHODOLOGY:
Six electronic databases were searched from inception until November 2011 for human interventional and preclinical evidence pertaining to the safety and efficacy of green tea for lung cancer.

RESULTS:
A total of 84 articles met inclusion criteria: two Phase I trials, three reports of one surrogate study, and 79 preclinical studies. There is a lack of controlled trials investigating green tea for lung cancer. Two Phase I studies showed no objective tumor responses at the maximum tolerated dose, ranging from 3 to 4.2 g/m(2) green tea extract (GTE) per day. Four cups of green tea daily decreased DNA damage (8OH-dG) in smokers. Human studies indicate that 800mg of green tea catechins daily does not alter activity of the CYP2D6, CYP1A2, CYP3A4 and CYP2C9 enzymes, however in vitro evidence suggests that green tea may bind to and reduce the effectiveness of bortezomib. Green tea applied topically may improve the healing time of radiation burns.

CONCLUSIONS:
Although some evidence suggests that chemopreventative benefits can be accrued from green tea, there is currently insufficient evidence to support green tea as a treatment or preventative agent for lung cancer. Green tea should not be used by patients on bortezomib therapy. Further research is warranted to explore this natural agent for lung cancer treatment and prevention.

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