KMCRIC

Systematic review of traditional Chinese medicine for depression in Parkinson's disease.

Zhang Y, Wang ZZ, Sun HM, Li P, Li YF, Chen NH.

Am J Chin Med.

2014

42(5)

1035-1051.

10.1142/S0192415X14500657.

25183301

http://www.ncbi.nlm.nih.gov/pubmed/25183301

Clinical Trials as Topic
Databases, Bibliographic*
Depression/drug therapy*
Depression/etiology*
Drugs, Chinese Herbal/therapeutic use*
Humans
Medicine, Chinese Traditional*
Parkinson Disease/complications*
Research Design

Depression; Non-Motor Symptom; Parkinson's Disease; Systematic Review; Traditional Chinese Medicine

우울증; 비운동 증상; 파킨슨 병; 체계적 문헌고찰; 중의학

KMCRIC 비평 보기 +

Depression is the most common non-motor symptom of Parkinson's disease (PD). Recent clinical trials have evaluated the effectiveness of traditional Chinese medicine (TCM) in the treatment of depression in PD (dPD). However, the results are conflicting rather than conclusive. To investigate the effectiveness of TCM for the treatment of dPD, a systematic review was conducted. Literature searches and collections were performed to identify studies addressing the treatment of TCM for dPD. The methodological quality and risk of bias in all studies included were evaluated. Weighted mean difference (WMD) with 95% confidence interval (CI) was used as the effect measure. Finally, a total of 10 studies involving 582 patients were identified. The pooled results revealed that TCM combined with conventional drugs significantly improved the total scores of the unified Parkinson's disease rating scale (WMD = -7.35, 95% CI: -11.24 to -3.47) and the score of the Hamilton rating scale for depression (HAM-D) (WMD = -4.19, 95% CI: -5.14 to -3.24) compared with conventional drug, respectively. Conclusively, there is evidence that TCM may be beneficial to the treatment of dPD in spite of the methodological weakness of the included studies.

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