KMCRIC

Chinese herbal medicine for coronavirus disease 2019: A systematic review and meta-analysis.

Xiong X, Wang P, Su K, Cho WC, Xing Y.

Pharmacol Res.

2020

160

105056.

10.1016/j.phrs.2020.105056.

32622723

http://www.ncbi.nlm.nih.gov/pubmed/32622723

COVID-19
Coronavirus Infections / complications
Coronavirus Infections / drug therapy*
Drugs, Chinese Herbal / adverse effects
Drugs, Chinese Herbal / therapeutic use*
Humans
Medicine, Chinese Traditional
Pandemics
Pneumonia, Viral / complications
Pneumonia, Viral / drug therapy*
Randomized Controlled Trials as Topic

Chinese herbal medicine; Coronavirus disease 2019; Meta-analysis; Randomized controlled trial; Systematic review; Traditional Chinese medicine

중약; COVID-19; 메타분석; 무작위배정 비교임상연구; 체계적 문헌고찰; 중의학

KMCRIC 비평 보기 +

Currently, coronavirus disease 2019 (COVID-19), which can lead to severe respiratory failure and death, is now a global pandemic with no specific anti-viral drugs or vaccines. However, It is worth noting that traditional Chinese medicine (TCM), especially Chinese herbal medicine (CHM), has been widely applied in mainland China since outbreak, bringing new hope for the prevention and control of COVID-19. A comprehensive literature searching was conducted in 7 electronic databases from their inception up to June 21, 2020 to evaluate the efficacy and safety of CHM for COVID-19. Eighteen randomized controlled trials (RCTs) involving 2275 patients were enrolled. Most of CHMs were originated from classical Chinese herbal formulas. Liquoric Root (Gancao, Radix Glycyrrhizae), Baical Skullcap Root (Huangqin, Radix Scutellariae Baicalensis), Pinellia Rhizome (Banxia, Rhizoma Pinelliae Tematae), Forsythia Fruit (Lianqiao, Fructus Forsythiae Suspensae), and Bitter Apricot Seed (Kuxingren, Semen Armeniacae Amarum) were most frequently used Chinese herbs. The most commonly used dosage formulation was decoction. Our meta-analyses found that comparing CHM group and conventional western medicine group, CHM group has improvements in several clinical parameters including lung CT, clinical cure rate, ranging from mild to critical cases, length of hospital stay, total score of clinical symptoms, fever reduction time, symptom score of fever, number of cough reduction cases, symptom score of cough, number of fatigue reduction cases, symptom score of fatigue, disappearing time of fatigue, TCM syndrome, viral nucleic acid testing, and inflammatory biomarkers (C-reactive protein). Besides, no severe adverse effects was identified by CHM. CHM, especially classical Chinese herbal formulas, could be used as potential candidates for COVID-19 in this battle.

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