플러스100%마이너스

통합검색
닫기

KMCRIC 챗봇에게

질문하기!

한의약융합데이터센터


근거중심한의약 DB

Home > 한의약융합데이터센터 > 근거중심한의약 DB
Title

Safety of essential bee venom pharmacopuncture as assessed in a randomized controlled double-blind trial.

Authors

Ahn YJ, Shin JS, Lee J, Lee YJ, Kim MR, Shin YS, Park KB, Kim EJ, Kim MJ, Lee JW, Lee HD, Lee Y, Kim S, Chung HJ, Ha IH.

Journal

J Ethnopharmacol.

Year

2016

Vol (Issue)

194

Page

774-80.

doi

10.1016/j.jep.2016.11.012.

PMID

27840257

Url

http://www.ncbi.nlm.nih.gov/pubmed/27840257

MeSH

Acupuncture/methods
Adult
Animals
Bee Venoms/administration & dosage*
Bee Venoms/immunology*
Cell Line
Double-Blind Method
Female
Forearm
Humans
Hypersensitivity/diet therapy*
Hypersensitivity/immunology
Insect Bites and Stings/drug therapy*
Insect Bites and Stings/immunology*
Lipopolysaccharides/immunology
Macrophages/immunology
Male
Mice
Nitric Oxide/immunology
Phospholipases A2/immunology

Keywords

Bee venoms; Drug-related side effects and adverse reactions; Drug hypersensitivity; Safety; Toxicity; Anti-inflammatory agents

한글 키워드

봉독약침; 약물 관련 부작용 및 유해 반응; 약물 과민증; 안전성; 독성; 항염증제

KMCRIC
Summary & Commentary

KMCRIC 비평 보기 +

Korean Study

Y

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:
While bee venom (BV) pharmacopuncture use is common in Asia, frequent occurrence of allergic reactions during the treatment process is burdensome for both practitioner and patient.
AIM OF THE STUDY:
This study compared efficacy and safety in isolated and purified essential BV (eBV) pharmacopuncture filtered for phospholipase A2 (PLA2) and histamine sections, and original BV to the aim of promoting safe BV pharmacopuncture use.
MATERIALS AND METHODS:
In in vitro, we examined the effect of BV and eBV on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW 264.7 macrophages, and clinically, 20 healthy adults aged 20-40 years were randomly allocated and administered eBV 0.2mL and BV pharmacopuncture 0.2mL on left and right forearm, respectively, and physician, participant, and outcome assessor were blinded to treatment allocation. Local pain, swelling, itching, redness, wheals, and adverse reactions were recorded by timepoint.
RESULTS:
eBV and BV exhibited similar inhibitory effects on NO production. Also, in comparison between eBV and BV pharmacopuncture administration areas on each forearm, eBV displayed significantly lower local pain at 24h post-administration (P=0.0062), and less swelling at 30min (P=0.0198), 2 (P=0.0028), 24 (P=0.0068), and 48h post-administration (P=0.0253). eBV also showed significantly less itching at 24 (P=0.0119), 48 (P=0.0082), and 96h (P=0.0141), while redness was significantly less at 30min (P=0.0090), 6 (P=0.0005), and 24h (P<0.0001). Time-by-treatment interactions were statistically significant for itching and redness (P<0.001, and P<0.001, respectively), and all original BV pharmacopuncture administered regions showed a tendency toward more severe itching and redness in later measurements.
CONCLUSIONS:
eBV and BV displayed comparable anti-inflammatory effects, and eBV pharmacopuncture presented less local allergic reactions.

국문초록

Language

영어

첨부파일