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Title

Probiotics and respiratory and gastrointestinal tract infections in Finnish military conscripts - a randomized placebo-controlled double-blinded study.

Authors

Kalima K, Lehtoranta L, He L, Pitkäniemi J, Lundell R, Julkunen I, Roivainen M, Närkiö M, Mäkelä MJ, Siitonen S, Korpela R, Pitkäranta A.

Journal

Benef Microbes.

Year

2016

Vol (Issue)

7(4)

Page

463-71.

doi

10.3920/BM2015.0172.

PMID

27048835

Url

http://www.ncbi.nlm.nih.gov/pubmed/27048835

MeSH

Keywords

Lactobacillus; Bifidobacterium; military medicine

한글 키워드

락토바실러스; 비피더스균; 군의학

KMCRIC summary and commentary

없음

Korean Study

Abstract

Military conscripts are susceptible to respiratory and gastrointestinal tract infections. In previous studies probiotics have shown potency to reduce upper respiratory and gastrointestinal infections. The aim was to study whether probiotic intervention has an impact on seasonal occurrence of upper respiratory and gastrointestinal infections in two different conscript groups. In a randomised, double-blinded, placebo controlled study (https://clinicaltrials.gov NCT01651195), a total of 983 healthy adults were enrolled from two intakes of conscripts. Conscripts were randomised to receive either a probiotic combination of Lactobacillus rhamnosus GG (LGG) and Bifidobacterium animalis ssp. lactis BB12 (BB12) or a control chewing tablet twice daily for 150 days (recruits) or for 90 days (reserve officer candidates). Clinical examinations were carried out and daily symptom diaries were collected. Outcome measures were the number of days with respiratory and gastrointestinal symptoms and symptom incidence, number and duration of infection episodes, number of antibiotic treatments received and number of days out of service because of the infection. Statistically no significant differences were found between the intervention groups either in the risk of symptom incidence or duration. However, probiotic intervention was associated with reduction of specific respiratory infection symptoms in military recruits, but not in reserve officer candidates. Probiotics did not significantly reduce overall respiratory and gastrointestinal infection morbidity.

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