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한의약융합데이터센터


근거중심한의약 DB

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Title

Seven-Year Follow-up of Children Born to Women in a Randomized Trial of Prenatal DHA Supplementation.

Authors

Gould JF, Treyvaud K, Yelland LN, Anderson PJ, Smithers LG, McPhee AJ, Makrides M.

Journal

JAMA.

Year

2017

Vol (Issue)

317(11)

Page

1173-75.

doi

10.1001/jama.2016.21303.

PMID

28324081

Url

http://www.ncbi.nlm.nih.gov/pubmed/28324081

MeSH

Age Factors
Child
Child Behavior/drug effects
Child Development/drug effects*
Child, Preschool
Cognition/drug effects
Dietary Supplements*
Docosahexaenoic Acids/administration & dosage*
Double-Blind Method
Educational Status
Executive Function/drug effects
Female
Follow-Up Studies
Humans
Infant
Intelligence/drug effects*
Language Development
Motor Skills/drug effects
Pregnancy
Prenatal Care*
Time Factors

Keywords

한글 키워드

KMCRIC
Summary & Commentary

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Korean Study

Abstract

The sale of prenatal supplements with docosahexaenoic acid (DHA) continues to increase, despite little evidence of benefit to offspring neurodevelopment.1 We randomized pregnant women to receive 800 mg of DHA daily or a placebo during the last half of pregnancy and found no group differences in cognitive, language, and motor development at 18 months of age, although secondary analyses revealed less cognitive delay but lower language scores in the DHA group.2 At 4 years of age there was no benefit of DHA supplementation in general intelligence, language, and executive functioning, and a possible negative effect on parent-rated behavior and executive functioning.3 This follow-up was designed to evaluate the effect of prenatal DHA on intelligence quotient (IQ) at 7 years, the earliest age at which adult performance can be indicated.

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