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Oral Administration of Probiotic Lactobacillus Casei Shirota Decreases Pneumonia and Increases Pulmonary Functions after Single Rib Fracture: A Randomized Double-Blind, Placebo-Controlled Clinical Trial.

Guo C, Lei M, Wang Y, Hua L, Xue S, Yu D, Zhang C, Wang D.

J Food Sci.

2018

83(8)

2222-6.

10.1111/1750-3841.14220.

30020533

http://www.ncbi.nlm.nih.gov/pubmed/30020533

Administration, Oral
Aged
Animals
Double-Blind Method
Female
Humans
Lactobacillus casei*
Lung/physiopathology*
Male
Middle Aged
Milk
Pneumonia/epidemiology
Pneumonia/etiology
Pneumonia/prevention & control*
Probiotics/administration & dosage*
Rib Fractures/complications*
Rib Fractures/physiopathology

Lactobacillus casei Shirota; pneumonia; probiotics; pulmonary functions; single rib fracture

락토바실러스 카제이 시로타; 폐렴; 프로바이오틱스; 폐 기능; 단일 늑골 골절

없음

Considerate proportion of elderly patients with a rib fracture is susceptible to pulmonary complications, especially pneumonia. We aimed to assess the effect of oral administration of the probiotic Lactobacillus casei Shirota (LcS) on pneumonia and pulmonary functions among elderly patients with single rib fracture. The current study including 204 eligible elderly patients with a single rib fracture was conducted. Patients were randomly assigned to receive oral administration of skimmed milk containing either a commercial probiotic LcS or placebo daily for 1 mo after the fracture, followed by pneumonia assessments, pulmonary function testing including forced expiratory volume (FEV), negative inspiratory pressure (NIP), and forced vital capacity (FVC), as well as evaluation of potential adverse effects including myocardial infarction, acute kidney injury, nonunion of fractured bone, or stroke. After 1 mo consumption, patients in the LcS group exhibited decreased pneumonia and increased recovery of pulmonary functions, in terms of FEV, FVC, and NIP, compared to the placebo group. No difference was observed in incidence of adverse events between the 2 groups. In patients with a single rib fracture, oral administration of the probiotic LcS was associated with a lower incidence of pneumonia and increased pulmonary functions without causing severe adverse effects.

PRACTICAL APPLICATION:

To conclude, after 1-mo LcS consumption, in patients with a single rib fracture, oral administration of the probiotic LcS was associated with a lower incidence of pneumonia and increased pulmonary functions without causing severe adverse effects.

© 2018 Institute of Food Technologists®.

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