KMCRIC

Wrinkle reduction using a Sasang constitutional medicine-based topical herbal cream in So-eum subjects: A split-face randomized double-blind placebo-controlled study.

Im AR, Ji KY, Nam J, Yoon J, Cha S, Seo YK, Chae S, Kim JY.

Integr Med Res.

2022

11(1)

100752.

10.1016/j.imr.2021.100752.

34345586

http://www.ncbi.nlm.nih.gov/pubmed/34345586

Medicine, Korean Traditional
Skin Aging
Skin Cream

Anti-wrinkle; Herbal medicine; Sasang constitutional medicine; So-eum type

주름 억제; 한약; 사상체질의학; 소음인

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Y

Background: Skin aging is caused by exogenous and endogenous factors and is commonly manifested as wrinkling, sagging, and looseness of the skin. The herbal extract including Zingiber officinale Roscoe, Atractylodes chinensis (Bunge) Kodiz, Curcuma longa L., and Cinnamomum cassia (L.) J.Presl (ZACC extract), is widely used for So-eum (SE) Sasang constitutional type individuals. This study aimed to examine the protective effects of the ZACC extract against skin aging in 21 SE type subjects.

Methods: The safety and clinical efficacy of herbal cream were evaluated after application on human skin in a split-face randomized, double-blind, placebo-controlled study. The Sasang Constitution Analysis Tool (SCAT) was used to select 21 SE type subjects, who applied herbal cream and placebo cream for 12 weeks. Visual assessment, wrinkle parameters, questionnaires, and skin safety were evaluated.

Results: The visual assessment score was decreased by using of the herbal cream, but there were no significant differences between groups. Among the wrinkle parameters, R1 (skin roughness) and R4 (smoothness depth) values were significantly improved after the application of the herbal cream compared to those observed after application of the placebo cream for 12 weeks. No significant differences were observed in evaluation of the product efficacy and usability by questionnaires. There were no adverse dermatologic reactions in the SE type subjects during the evaluation period.

Conclusion: The ZACC herbal cream may be used to prevent or slow skin aging, including wrinkle formation, in SE type individuals.

© 2021 Published by Elsevier B.V. on behalf of Korea Institute of Oriental Medicine.

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