플러스100%마이너스

통합검색
닫기

KMCRIC 챗봇에게

질문하기!

한의약융합데이터센터


근거중심한의약 DB

Home > 한의약융합데이터센터 > 근거중심한의약 DB
Title

Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis.

Authors

Liu X, Machado GC, Eyles JP, Ravi V, Hunter DJ.

Journal

Br J Sports Med.

Year

2018

Vol (Issue)

52(3)

Page

167-75.

doi

10.1136/bjsports-2016-097333.

PMID

29018060

Url

http://www.ncbi.nlm.nih.gov/pubmed/29018060

MeSH

Biological Products/therapeutic use
Dietary Supplements*
Humans
Osteoarthritis/therapy*
Pain/physiopathology
Pain Management
Plant Preparations/therapeutic use
Randomized Controlled Trials as Topic

Keywords

evidence based review; meta-analysis; osteoarthritis; supplements

한글 키워드

근거기반 리뷰; 메타분석; 골관절염; 보충제

KMCRIC
Summary & Commentary

KMCRIC 비평 보기 +

Korean Study

Abstract

OBJECTIVE:
To investigate the efficacy and safety of dietary supplements for patients with osteoarthritis.

DESIGN:
An intervention systematic review with random effects meta-analysis and meta-regression.

DATA SOURCES:
MEDLINE, EMBASE, Cochrane Register of Controlled Trials, Allied and Complementary Medicine and Cumulative Index to Nursing and Allied Health Literature were searched from inception to April 2017.

STUDY ELIGIBILITY CRITERIA:
Randomised controlled trials comparing oral supplements with placebo for hand, hip or knee osteoarthritis.

RESULTS:
Of 20 supplements investigated in 69 eligible studies, 7 (collagen hydrolysate, passion fruit peel extract, Curcuma longa extract, Boswellia serrata extract, curcumin, pycnogenol and L-carnitine) demonstrated large (effect size >0.80) and clinically important effects for pain reduction at short term. Another six (undenatured type II collagen, avocado soybean unsaponifiables, methylsulfonylmethane, diacerein, glucosamine and chondroitin) revealed statistically significant improvements on pain, but were of unclear clinical importance. Only green-lipped mussel extract and undenatured type II collagen had clinically important effects on pain at medium term. No supplements were identified with clinically important effects on pain reduction at long term. Similar results were found for physical function. Chondroitin demonstrated statistically significant, but not clinically important structural improvement (effect size -0.30, -0.42 to -0.17). There were no differences between supplements and placebo for safety outcomes, except for diacerein. The Grading of Recommendations Assessment, Development and Evaluation suggested a wide range of quality evidence from very low to high.

CONCLUSIONS:
The overall analysis including all trials showed that supplements provided moderate and clinically meaningful treatment effects on pain and function in patients with hand, hip or knee osteoarthritis at short term, although the quality of evidence was very low. Some supplements with a limited number of studies and participants suggested large treatment effects, while widely used supplements such as glucosamine and chondroitin were either ineffective or showed small and arguably clinically unimportant treatment effects. Supplements had no clinically important effects on pain and function at medium-term and long-term follow-ups.

국문초록

Language

영어

첨부파일