KMCRIC

Effects of neuromuscular electrical stimulation on glycemic control: a systematic review and meta-analysis.

Sanchez MJ, Mossayebi A, Sigaroodi S, Apaflo JN, Galvan MJ, Min K, Agullo FJ, Wagler A, Bajpeyi S.

Front Endocrinol (Lausanne).

2023

14

1222532.

10.3389/fendo.2023.1222532.

37583429

http://www.ncbi.nlm.nih.gov/pubmed/37583429

Aged
Diabetes Mellitus, Type 2* / therapy
Electric Stimulation
Electric Stimulation Therapy* / methods
Health Services
Humans
Middle Aged
Obesity

NMES; e-stim; glucose; insulin sensitivity; metabolic health; muscle; myostimulation; substrate utilization

없음

N

Background: Physical inactivity increases the risk for metabolic diseases such as obesity and type 2 diabetes. Neuromuscular electrical stimulation (NMES) is an effective method to induce muscle contraction, particularly for populations with physical impairments and/or metabolic diseases. However, its effectiveness to improve glycemic control is unclear. This review aimed to determine the effectiveness of NMES on glycemic control.

Methods: Electronic search consisted of MEDLINE (PubMed), EMBASE, Cochrane Library, Google Scholar, and Web of Science to identify studies that investigated the effects of NMES on glycemic control for this systematic review. The meta-analysis consists of the studies designed as randomized controlled trials. Effect sizes were calculated as the standardized mean difference (SMD) and meta-analysis was conducted using a random-effects model.

Results: Thirty-five studies met the inclusion criteria for systematic review and of those, nine qualified for the meta-analysis. Existing evidence suggested that NMES effectively improves glycemic control predominantly in middle-aged and elderly population with type 2 diabetes, obesity, and spinal cord injury. The meta-analysis is comprised of 180 participants and reported that NMES intervention lowered fasting blood glucose (SMD: 0.48; 95% CI: 0.17 to 0.78; p=0.002; I²=0%). Additional analysis using the primary measures reported by each study to indicate glycemic control (i.e., OGTT, HOMA-IR, and fasting glucose) also confirmed a significant effect of NMES on improving glycemic control (SMD: 0.41; 95% CI, 0.09 to 0.72; p=0.01; I²=11%). NMES protocol varied across studies and requires standardization.

Conclusion: NMES could be considered as a therapeutic strategy to improve glycemic control in populations with physical impairments and/or metabolic disorders.

Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42020192491.

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