한의약융합데이터센터
한의약융합데이터 콘텐츠 바로가기
생약 up-to-date
Home > 한의약융합데이터센터 > 생약 up-to-date
맥문동
麥門冬
- ※ 생약 정보 공유 시 출처: KMCRIC 생약 up-to-date을 꼭 표기해 주세요.
- ※ 사진 정보 공유 시 출처: KIOM 본초감별도감을 꼭 표기해 주세요.
일반정보
| 일반명 | Liriope tuber, ophiopogon |
|---|---|
| 라틴명 | Liriopis Tuber |
| 이명 | 촌동(寸冬), 대맥동(大麥冬), 맥동(麥冬), 여동(麗冬) |
| 학명 | Liriope platyphylla Wang et Tang (맥문동), Ophiopogon japonicus Ker-Gawler (소엽맥문동) |
| 기원 | 맥문동 Liriope platyphylla Wang et Tang 또는 소엽맥문동 Ophiopogon japonicus Ker-Gawler (백합과 Liliaceae)의 뿌리의 팽대부 |
| 약성/귀경 | 달고(甘) 약간 쓰고(微苦) 약간 차다(微寒). 폐(肺), 심(心), 위경(胃經)에 작용한다. |
| 효능 | 윤폐양음(潤肺養陰), 익위생진(益胃生津), 청심제열(淸心除熱), 겸능윤장(兼能潤腸) 윤폐(潤肺): a therapeutic method to treat lung dryness pattern/syndrome by using moistening medicinals 양음약(養陰藥): a medicinal that tonifies and nourishes yin fluid, the same as the yin-nourishing or yin-replenishing medicinal 양위(養胃): a therapeutic method to treat stomach yin deficiency pattern/syndrome, the same as to tonify the stomach yin or to nourish the stomach 생진(生津): a therapeutic method to treat fluid depletion with fluid-nourishing medicinals 청심(淸心): a therapeutic method to treat pathogen entering the heart or pericardium in a warm disease 청열(淸熱): a therapeutic method of clearing pathogenic heat 윤장(潤腸): a therapeutic method for constipation due to intestinal dryness by using moistening medicinals |
성분정보
*계열/성분을 클릭하면 구조 및 상세정보를 볼 수 있습니다.
일반정보
| 일반명 | Liriope tuber, ophiopogon |
|---|---|
| 라틴명 | Liriopis Tuber |
| 이명 | 촌동(寸冬), 대맥동(大麥冬), 맥동(麥冬), 여동(麗冬) |
| 학명 | Liriope platyphylla Wang et Tang (맥문동), Ophiopogon japonicus Ker-Gawler (소엽맥문동) |
| 기원 | 맥문동 Liriope platyphylla Wang et Tang 또는 소엽맥문동 Ophiopogon japonicus Ker-Gawler (백합과 Liliaceae)의 뿌리의 팽대부 |
| 약성/귀경 | 달고(甘) 약간 쓰고(微苦) 약간 차다(微寒). 폐(肺), 심(心), 위경(胃經)에 작용한다. |
| 효능 | 윤폐양음(潤肺養陰), 익위생진(益胃生津), 청심제열(淸心除熱), 겸능윤장(兼能潤腸) 윤폐(潤肺): a therapeutic method to treat lung dryness pattern/syndrome by using moistening medicinals 양음약(養陰藥): a medicinal that tonifies and nourishes yin fluid, the same as the yin-nourishing or yin-replenishing medicinal 양위(養胃): a therapeutic method to treat stomach yin deficiency pattern/syndrome, the same as to tonify the stomach yin or to nourish the stomach 생진(生津): a therapeutic method to treat fluid depletion with fluid-nourishing medicinals 청심(淸心): a therapeutic method to treat pathogen entering the heart or pericardium in a warm disease 청열(淸熱): a therapeutic method of clearing pathogenic heat 윤장(潤腸): a therapeutic method for constipation due to intestinal dryness by using moistening medicinals |
| 관련링크명 | 구분 | URL | 바로가기 |
|---|---|---|---|
| 농촌진흥청 농업기술길잡이 | www.nongsaro.go.kr/portal/ps/psb/psbx/cropEbookLst.ps?menuId=PS65290&stdPrdlstCode=IC&sStdPrdlstCode=IC0319ZZ# | 바로가기+ | |
| 식약처 생약종합정보시스템 | 맥문동 | www.nifds.go.kr/nhmi/hbdc/ofcmhbdc/view.do?selectedDmstcOfcmNo=152&selectedMdntfNo=258 | 바로가기+ |
| 식약처 생약종합정보시스템 | 소엽맥문동 | www.nifds.go.kr/nhmi/hbdc/ofcmhbdc/view.do?selectedDmstcOfcmNo=152&selectedMdntfNo=259 | 바로가기+ |
주요성분 (5)
| 계열 | 성분 | 구조 | 링크 | 효능 |
|---|---|---|---|---|
| saponin | ophiopogonin A |
|
|
자양강장, 진해거담 |
| saponin | ophiopogonin B |
|
|
자양강장, 항암 |
| saponin | ophiopogonin D |
|
|
자양강장, 골다공증 치료 |
| isoflavonoid | ophiopogonone A |
|
|
자양강장 |
| isoflavonoid | ophiopogonanone A |
|
|
자양강장 |
신규성분 (23)
| 계열 | 성분 | 구조 | 서지사항 |
|---|---|---|---|
| saponin | 25(R, S)-ruscogenin-1-O-[β-D-fucopyranosyl (1→2)]-[β-D-xylopyranosyl(1→3)]β-D-glucopyranoside (Liriopem I, 1), 25(R, S)-ruscogenin-1-O-[β-D-fucopyranosyl (1→2)]-[β-D-xylopyranosyl(1→4)]-β-D-fucopyranoside (Liriopem II, 2) |
|
Li YW, Qi J, Zhang YY, Huang Z, Kou JP, Zhou SP, Zhang Y, Yu BY. Novel cytotoxic steroidal glycosides from the roots of Liriope muscari. Chin J Nat Med. 2015 Jun;13(6):461-6. PubMed |
| etc | (2R)-(2',4'-dihydroxybenzyl)-6,7-methylenedioxy-2,3-dihydrobenzofuran |
|
Tsai YC, Hsu CC, El-Shazly M, Chiang SY, Wu CC, Wu CC, Lai WC, Yen MH, Wu YC, Chang FR. Phytochemicals and Estrogen-Receptor Agonists from the Aerial Parts of Liriope platyphylla. Molecules. 2015 Apr 16;20(4):6844-55. PubMed |
| coumarin | 3-(2'-hydroxyphenyl)-6,8-dihydroxy-7-methoxy-isocoumarin (2), platyphyllarin C (3) |
|
Tsai YC, Hsu CC, El-Shazly M, Chiang SY, Wu CC, Wu CC, Lai WC, Yen MH, Wu YC, Chang FR. Phytochemicals and Estrogen-Receptor Agonists from the Aerial Parts of Liriope platyphylla. Molecules. 2015 Apr 16;20(4):6844-55. PubMed |
| saponin | (25R)-spirost-5,8(14)-diene-3β-ol (1), ruscogenin 1-O-α-L-rhamnopyranosyl-(1→2)-4-O-sulfo-α-L-arabinopyranoside-3-O-β-D-glucopyranoside (2) |
|
Qi J, Hu ZF, Zhou YF, Hu YJ, Yu BY. Steroidal sapogenins and glycosides from the fibrous roots of Ophiopogon japonicus and Liriope spicata var. prolifera with anti-inflammatory activity. Chem Pharm Bull (Tokyo). 2015;63(3):187-94. PubMed |
| etc | (2R)-(4-methoxybenzyl)-5,7-dimethyl-6-hydroxyl-2,3-dihydrobenzofuran (1), 2-(2-hydroxyl-4-methoxy-benzyl)-5-methyl-6-methoxyl-2,3-dihydrobenzofuran (2), 2-(4-hydroxy-benzyl)-5,6-dihydroxybenzofuran (3) |
|
Dang NH, Chung ND, Tuan HM, Van Thanh N, Hiep NT, Lee D, Dat NT. 2-Benzyl-benzofurans from the tubers of Ophiopogon japonicus. Chem Cent J. 2017 Feb 6;11:15. PubMed |
| saponin | ophiojaponins A-E |
|
Wang L, Jiang XL, Zhang WM, Li F, Khan AA, Liu X, Yu K, Wang MK. Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogon japonicus. Phytochemistry. 2017 Apr;136:125-132. PubMed |
| flavonoid | homoisopogon A (1), homoisopogon B-D (2-4) |
|
Dang NH, Chung ND, Tuan HM, Hiep NT, Dat NT. Cytotoxic Homoisoflavonoids from Ophiopogon japonicus Tubers. Chem Pharm Bull (Tokyo). 2017 Feb 1;65(2):204-207. PubMed |
| sesquiterpene | cryptomeridiol 11-O-β-d-xylopyranosyl-(1→6)-β-d-glucopyranoside |
|
Liu SQ, Kang LP, Zhang J, Liu YX, Zhao Y, Liu B, Ma BP. New sesquiterpenoid glycoside and phenylpropanoid glycosides from the tuber of Ophiopogon japonicus. J Asian Nat Prod Res. 2016 Jun;18(6):520-7. PubMed |
| phenolic | 3,4-dihydroxy-allylbenzene 3-O-β-d-glucopyranosyl-4-O-β-d-apiofuranosyl-(1→6)-β-d-glucopyranoside (2), 3,4,5-trihydroxy-allylbenzene 3-O-β-d-glucopyranosyl-4-O-β-d-glucopyranoside (3) |
|
Liu SQ, Kang LP, Zhang J, Liu YX, Zhao Y, Liu B, Ma BP. New sesquiterpenoid glycoside and phenylpropanoid glycosides from the tuber of Ophiopogon japonicus. J Asian Nat Prod Res. 2016 Jun;18(6):520-7. PubMed |
| saponin | (20R,25R)-26-O-β-d-glucopyranosyl-3β,26-dihydroxycholest-5-en-16,22-dioxo-3-O-α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranoside (1) 26-O-β-d-glucopyranosyl-(25R)-furost-5-en-3β,14α,17α,22α,26-pentaol-3-O-α-l-rhamnopyranosyl-(1→2)-β-d-glucopyranoside (3) |
|
Liu Y, Meng LZ, Xie SX, Xu TH, Sun LK, Liu TH, Xu YJ, Xu DM. Studies on chemical constituents of Ophiopogon japonicus. J Asian Nat Prod Res. 2014 Oct;16(10):982-90. PubMed |
| saponin | ophiopogonins J (1), K (2) |
|
Kang ZY, Zhang MJ, Wang JX, Liu JX, Duan CL, Yu DQ. Two new furostanol saponins from the fibrous root of Ophiopogon japonicus. J Asian Nat Prod Res. 2013;15(12):1230-6. PubMed |
| saponin | (25R)-26-O-[β-d-glucopyranosyl-(1→2)-β-d-glucopyranosyl]-5-ene-furost-1β,3β,22α,26-tetraol-3-O-α-l-rhamnopyranosyl-(1→2)-[β-d-xylopyranosyl-(1→4)]-β-d-glucopyranoside (1, ophiopogonin P), (25R)-26-O-[β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl]-5-ene-furost-1β,3β,22α,26-tetraol-3-O-α-l-rhamnopyranosyl-(1→2)-[β-d-xylopyranosyl-(1→4)]-β-d-glucopyranoside (2, ophiopogonin Q) |
|
Guo Y, Liu YX, Kang LP, Zhang T, Yu HS, Zhao Y, Xiong CQ, Ma BP. Two novel furostanol saponins from the tubers of Ophiopogon japonicus. J Asian Nat Prod Res. 2013;15(5):459-65. PubMed |
| etc | ophiogenin |
|
Lan S, Yi F, Shuang L, Chenjie W, Zheng XW. Chemical constituents from the fibrous root of Ophiopogon japonicus, and their effect on tube formation in human myocardial microvascular endothelial cells. Fitoterapia. 2013 Mar;85:57-63. PubMed |
| sesquiterpene | ophioside A |
|
Lan S, Yi F, Shuang L, Chenjie W, Zheng XW. Chemical constituents from the fibrous root of Ophiopogon japonicus, and their effect on tube formation in human myocardial microvascular endothelial cells. Fitoterapia. 2013 Mar;85:57-63. PubMed |
| saponin | ophiopogonin P-S (1-4) |
|
Li N, Zhang L, Zeng KW, Zhou Y, Zhang JY, Che YY, Tu PF. Cytotoxic steroidal saponins from Ophiopogon japonicus. Steroids. 2013 Jan;78(1):1-7. PubMed |
| flavonoid | ophiopogonone E (1), ophiopogonanone H (2) |
|
Li N, Zhang JY, Zeng KW, Zhang L, Che YY, Tu PF. Anti-inflammatory homoisoflavonoids from the tuberous roots of Ophiopogon japonicus. Fitoterapia. 2012 Sep;83(6):1042-5. PubMed |
| saponin | ophiopogonins H-O (1-8) |
|
Zhang T, Kang LP, Yu HS, Liu YX, Zhao Y, Xiong CQ, Zhang J, Zou P, Song XB, Liu C, Ma BP. Steroidal saponins from the tuber of Ophiopogon japonicus. Steroids. 2012 Oct;77(12):1298-305. PubMed |
| saponin | steroidal saponin |
|
Qu Y, Zhang Y, Pei L, Wang Y, Gao L, Huang Q, Ojika M, Sakagami Y, Qi J. New neuritogenic steroidal saponin from Ophiopogon japonicus (Thunb.) Ker-Gawl. Biosci Biotechnol Biochem. 2011;75(6):1201-4. PubMed |
| saponin | (25R)-14α, 17α-hydroxyspirost-5-en-3β-yl 3-O-α-L-rhamnpyranosyl-(1→2)-β-D-glucopyranosyl-(1→3)-β-D-glucopyranoside |
|
Wang Y, Xu J, Zhang L, Qu H. A new steroidal glycoside from the Ophiopogon japonicus Ker-Gawler (Liliaceae). Nat Prod Res. 2011 Jan;25(1):31-5. PubMed |
| saponin | ophiopogonins H (1), I (2) |
|
Duan CL, Ma XF, Jiang Y, Liu JX, Tu PF. Two new furostanol glycosides from the fibrous root of Ophiopogon japonicus (Thunb.) Ker-Gawl. J Asian Nat Prod Res. 2010 Sep;12(9):745-51. PubMed |
| flavonoid | homoisoflavonoids (1−3) |
|
Hung TM, Thu CV, Dat NT, Ryoo SW, Lee JH, Kim JC, Na M, Jung HJ, Bae K, Min BS. Homoisoflavonoid derivatives from the roots of Ophiopogon japonicus and their in vitro anti-inflammation activity. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2412-6. PubMed |
| saponin | ophiopogonin F(1), ophiopogonin G(2) |
|
Zhang T, Zou P, Kang LP, Yu HS, Liu YX, Song XB, Ma BP. Two novel furostanol saponins from Ophiopogon japonicus. J Asian Nat Prod Res. 2009 Sep;11(9):824-31. PubMed |
| flavonoid | ophiopogonone D (1), ophiopogonanone G (2) |
|
Duan CL, Kang ZY, Lin CR, Jiang Y, Liu JX, Tu PF. Two new homoisoflavonoids from the fibrous roots of Ophiopogon japonicus (Thunb.) Ker-Gawl. J Asian Nat Prod Res. 2009 Oct;11(10):876-9. PubMed |
약리정보
* 질병 분류 별 논문 수
| 질병 분류 | 임상 시험 human |
동물 실험 in vivo |
세포 및 시험관 실험 in vitro |
total (건) |
|---|---|---|---|---|
| 전염병 또는 기생충병(I) | 0 | 0 | 2 | 2 |
| 종양(II) | 0 | 0 | 5 | 5 |
| 혈액 및 혈액 생성 기관 질병으로 면역 체계와 관련된 병(III) | 0 | 2 | 0 | 2 |
| 내분비선 영양 및 순환계(IV) | 0 | 19 | 1 | 20 |
| 신경 계통의 질병(VI) | 0 | 1 | 3 | 4 |
| 눈과 그에 딸린 기관의 질병(VII) | 0 | 1 | 0 | 1 |
| 순환 계통의 질병(IX) | 0 | 9 | 3 | 12 |
| 호흡기 계통의 질병(X) | 1 | 4 | 2 | 7 |
| 소화 계통의 질병(XI) | 0 | 5 | 0 | 5 |
| 피부와 피하 조직의 질병(XII) | 1 | 1 | 1 | 3 |
| 근육과 연결 조직의 질병(XIII) | 0 | 1 | 1 | 2 |
| 항산화 또는 항염증(XXIII) | 0 | 1 | 3 | 4 |
| 합계 | 2 | 44 | 21 | 67 |
*숫자를 클릭하면 약리작용 상세정보를 볼 수 있습니다.