KMCRIC

The effect of herbal extract (EstroG-100) on pre-, peri- and post-menopausal women: a randomized double-blind, placebo-controlled study.

Chang A, Kwak BY, Yi K, Kim JS.

Phytother Res.

2012

26(4)

510-6.

10.1002/ptr.3597.

21887807

http://www.ncbi.nlm.nih.gov/pubmed/21887807

Adult
African Americans
Aged
Angelica/chemistry
Cynanchum/chemistry
Depressive Disorder/drug therapy
Double-Blind Method
European Continental Ancestry Group
Female
Hispanic Americans
Hot Flashes/drug therapy
Humans
Menopause/drug effects*
Menopause/metabolism
Middle Aged
Phlomis/chemistry
Phytotherapy*
Plant Extracts/therapeutic use*
Plant Roots/chemistry
Severity of Illness Index
Sleep Initiation and Maintenance Disorders/drug therapy
Treatment Outcome

menopausal symptom; vaginal dryness; EstroG-100; Cynanchum wilfordii; Phlomis umbrosa; Angelica gigas.

갱년기 증상; 질 건조증; 에스트로지; 큰조롱; 속단; 당귀

KMCRIC 비평 보기 +

This clinical research study was designed to evaluate the efficacy of a new herbal product, EstroG-100, containing a mixture of standardized extracts of Cynanchum wilfordii, Phlomis umbrosa and Angelica gigas, on menopausal symptoms. This randomized double-blind, placebo-controlled trial was performed for 12 weeks with 64 pre-, peri- and postmenopausal White Hispanic, White non-Hispanic and African American women who were randomly allocated to either the EstroG-100 group (n = 31) or the placebo group (n =  33). Primary end-points were the mean change in scores of the Kupperman menopause index (KMI) that evaluates 11 symptoms, and the mean change in scores of vaginal dryness. The mean KMI score was significantly reduced in the EstroG-100 group from 29.5 ± 7.4 at baseline to 11.3 ± 5.8 (p < 0.01) compared with change of the placebo group (29.2 ± 6.6 at baseline vs 23.7 ± 7.7 at week 12). The constituting symptoms of vasomotor, paresthesia, insomnia, nervousness, melancholia, vertigo, fatigue and rheumatic pain were significantly improved in the EstroG-100 group in comparison with the placebo group (p < 0.05). Statistically significant improvement in vaginal dryness in the EstroG-100 group was also observed compared with that of the placebo group (p < 0.05). In conclusion, EstroG-100 significantly improved the menopausal symptoms of pre-, peri- and post-menopausal women without weight gain or any serious side effects.

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