| Title |
Postprandial glucose-lowering effects of fermented red ginseng in subjects with impaired fasting glucose or type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial. |
| Authors |
Oh MR, Park SH, Kim SY, Back HI, Kim MG, Jeon JY, Ha KC, Na WT, Cha YS, Park BH, Park TS, Chae SW. |
| Journal |
BMC Complement Altern Med. |
| Year |
2014 |
| Vol (Issue) |
14 |
| Page |
237 |
| doi |
10.1186/1472-6882-14-237. |
| PMID |
25015735 |
| Url |
http://www.ncbi.nlm.nih.gov/pubmed/25015735 |
| MeSH |
Adult
Aged
Blood Glucose/drug effects*
Blood Glucose/metabolism
Diabetes Mellitus, Type 2/blood
Diabetes Mellitus, Type 2/drug therapy*
Double-Blind Method
Female
Humans
Hyperglycemia/blood
Hyperglycemia/drug therapy*
Hypoglycemic Agents/therapeutic use*
Insulin/blood
Male
Middle Aged
Panax/chemistry*
Plant Preparations/therapeutic use*
Young Adult |
| Keywords |
Fermented red ginseng; Type 2 diabetes; Impaired fasting glucose; Postprandial glucose |
| 한글 키워드 |
발효 홍삼; 제 2형 당뇨병; 공복혈당장애; 식후 혈당 |
KMCRIC
Summary & Commentary |
KMCRIC 비평 보기 + |
| Korean Study |
Y |
| Abstract |
BACKGROUND:
Red ginseng is prepared by steaming raw ginseng, a process believed to increase the pharmacological efficacy. Further bioconversion of red ginseng through fermentation is known to increase its intestinal absorption and bioactivity, and bioconversion diminishes the toxicity of red ginseng's metabolite. This study was conducted to investigate the effects of daily supplementation with fermented red ginseng (FRG) on glycemic status in subjects with impaired fasting glucose or type 2 diabetes.
METHODS:
This study was a four-week long, randomized, double-blind, placebo-controlled trial. Forty-two subjects with impaired fasting glucose or type 2 diabetes were randomly allocated to two groups assigned to consume either the placebo or fermented red ginseng (FRG) three times per day for four weeks. Fasting and postprandial glucose profiles during meal tolerance tests were assessed before and after the intervention.
RESULTS:
FRG supplementation led to a significant reduction in postprandial glucose levels and led to an increase in postprandial insulin levels compared to the placebo group. There was a consistently significant improvement in the glucose area under the curve (AUC) in the FRG group. However, fasting glucose, insulin, and lipid profiles were not different from the placebo group.
CONCLUSION:
Daily supplementation with FRG lowered postprandial glucose levels in subjects with impaired fasting glucose or type 2 diabetes. |
| 국문초록 |
|
| Language |
영어 |
| 첨부파일 |
|
