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Title

Efficacy of Panax ginseng supplementation on blood lipid profile. A meta-analysis and systematic review of clinical randomized trials.

Authors

Hernández-García D, Granado-Serrano AB, Martín-Gari M, Naudí A, Serrano JC.

Journal

J Ethnopharmacol.

Year

2019

Vol (Issue)

243

Page

112090.

doi

10.1016/j.jep.2019.112090.

PMID

31315027

Url

http://www.ncbi.nlm.nih.gov/pubmed/31315027

MeSH

Dietary Supplements
Humans
Lipids/blood*
Panax*
Phytotherapy
Plant Extracts/therapeutic use*
Randomized Controlled Trials as Topic
Treatment Outcome

Keywords

Blood lipid profile; Cholesterol; Panax ginseng

한글 키워드

KMCRIC
Summary & Commentary

KMCRIC 비평 보기 +

Korean Study

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:
Ginseng is a widely used ingredient in several traditional Chinese medicine formulation, mainly as a prophylactic and restorative agent. Ginseng's Chinese traditional formulations have shown protective effects against atherosclerosis, suggesting that ginseng may be useful for the treatment of metabolic disorders.

AIM OF THE STUDY:
To evaluate whether the supplementation with Panax ginseng (PG) has an effect on blood lipid profile in humans.

MATERIALS AND METHODS:
A meta-analysis and a systematic review were conducted to evaluate the effects of PG on blood lipid profile.

RESULTS:
A total of 18 studies met the inclusion criteria, from which 10 studies were performed in volunteers with at least one component of metabolic syndrome, 3 in postmenopausal women, 2 in healthy volunteers and 3 with other types of inclusion criteria. The doses employed ranged from 0.2 to 20 g/day (median 3 g/day, 95% CI 1.7, 5.8), while the treatment time ranged from 2 to 12 weeks (median 8 weeks, 95% CI 6, 9). Few studies reported the composition of the PG extract employed. The main ginsenosides reported were Rb1 and Rg1 (content ranging from Rb1 0.023-6.44 mg/g and Rg1 0.028-3.21 mg/g). Significant modification in blood profile was described in 7 studies, in which 5 studies observed a reduction in total cholesterol, 4 in LDL-cholesterol, and 2 in triacylglycerides. The meta-analysis of 10 studies in volunteers with parameters related with metabolic syndrome describes that PG may induce a mean difference compared to a placebo of -2.30 (95% CI -3.79,-0.80) and -1.47 (95% CI -1.90,-1.05) mg/dL per g/day of PG in the levels of total and LDL-cholesterol, with no significant effects in HDL-cholesterol and triacylglycerides.

CONCLUSIONS:
PG extract may induce an improvement in blood lipid profile mainly by a reduction in total and LDL-cholesterol levels.

Copyright © 2019 Elsevier B.V. All rights reserved.

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