KMCRIC

A Multidimensional Bayesian Network Meta-Analysis of Chinese Herbal Injections for Treating Non-small Cell Lung Cancer With Gemcitabine and Cisplatin.

Ni M, Wu Z, Wang H, Zhou W, Wu C, Stalin A, Fu C, Ye P, Lu S, Tan Y, Huang Z, Fan X, Zhang J, Zhang X, Wang M, Wu J.

Front Pharmacol.

2021

12

739673.

10.3389/fphar.2021.739673.

34552496

http://www.ncbi.nlm.nih.gov/pubmed/34552496

chinese herbal injections; gemcitabine plus cisplatin; multidimensional cluster; network meta-analysis; non-small cell lung cancer.

중약 주사제; 젬시타빈과 시스플라틴; 다차원적 클러스터; 네트워크 메타분석; 비소세포 폐암.

KMCRIC 비평 보기 +

Introduction: As non-small cell lung cancer (NSCLC) seriously threatens human health, several clinical studies have reported that Chinese herbal injections (CHIs) in combination with and gemcitabine plus cisplatin (GP) are beneficial. This multidimensional network meta-analysis aimed to compare the clinical efficacy and safety of different CHIs in combination with GP against NSCLC. Methods: Randomized controlled trials (RCTs) for the treatment of NSCLC were retrieved from seven electronic databases from inception to April 30, 2020. Study selection and data extraction were based on a priori criteria. Data analysis was performed using Stata 13.0, WinBUGS 14.0 software. Multidimensional cluster analysis was performed using the ""scatterplot3d"" package in R 3.6.1 software. Results: This network meta-analysis included 71 eligible RCTs and 10 Chinese herbal injections. Delisheng injection and Kangai injection had the highest probability in terms of clinical effectiveness rate (94.60%) and gastrointestinal reactions (82.62%) when combined with GP compared with the other interventions. Compound Kushen injection combined with GP ranked ahead of the other interventions in terms of performance status (73.36%) and abnormal liver function (87.17%). Shenmai injection combined with GP had the highest probability in terms of leukopenia (94.59%) and thrombocytopenia (99.18%). Conclusion: The current evidence revealed that CHIs combined with GP have a better impact on patients with NSCLC than GP alone. Aidi injection, Compound kushen injection, and Kanglaite injection deserve more attention of clinicians when combined with GP in patients with NSCLC. Additionally, due to the limitations of this network meta-analysis, further well-designed, large-sample, multicenter RCTs are required to support our findings adequately.

Copyright © 2021 Ni, Wu, Wang, Zhou, Wu, Stalin, Fu, Ye, Lu, Tan, Huang, Fan, Zhang, Zhang, Wang and Wu.

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