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| SCIENCE에 실린 코로나19 (COVID-19) 아티클 소개 (~3/18) |
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BLOGS | 18 March 2020 앤지오텐신과 코로나바이러스 Angiotensin and the Coronavirus By Derek Lowe https://blogs.sciencemag.org/pipeline/archives/2020/03/17/angiotensin-and-the-coronavirus
NEWS | 17 March 2020 한국에서 코로나바이러스 환자가 급감했다. 한국의 성공 비결은 무엇일까? Coronavirus cases have dropped sharply in South Korea. What’s the secret to its success? By Dennis Normile BLOGS | 16 March 2020 CureVac의 흥미로운 사례 The Curious Case of CureVac By Derek Lowe | Mar 16th, 2020 https://blogs.sciencemag.org/pipeline/archives/2020/03/16/curious-case-of-curevac NEWS | 16 March 2020 ‘똑딱이는 시한 폭탄': 과학자들은 아프리카의 코로나바이러스 확산 우려 ‘A ticking time bomb’: Scientists worry about coronavirus spread in Africa By Linda Nordling NEWS | 15 March 2020 전염병 전문가 Anthony Fauci를 만나다. 백악관의 코로나바이러스 대응 구체화 Meet Anthony Fauci, the epidemic expert trying to shape the White House’s coronavirus response By John Travis NEWS | 14 March 2020 왜 수십 가지의 질병이 계절에 따라 점점 쇠약해 지는가, 코로나도 그럴 것인가? Why do dozens of diseases wax and wane with the seasons—and will COVID-19? By Jon Cohen The calendar of epidemics At least 68 infectious diseases are seasonal, according to a 2018 paper by Micaela Martinez of Columbia University. But they’re not in sync, and seasonality varies by location. In this graphic, based on U.S. federal and state health records, each bubble represents the percentage of annual cases that occurred in each month. (The data are old because many diseases declined—in some cases to zero—after introduction of vaccines.)
(GRAPHIC) N. DESAI/SCIENCE; (INTERACTIVE) X. LIU/SCIENCE; (DATA) PROJECT TYCHO PERSPECTIVES AND COMMENTARY | 14 March 2020 부탁을 들어주세요. Do us a favor By H. Holden Thorp https://science.sciencemag.org/content/367/6483/1169 NEWS | 14 March 2020 유전체 분석을 통한 코로나바이러스의 경로 추적 Genome analyses help track coronavirus' moves By Kai Kupferschmidt https://science.sciencemag.org/content/367/6483/1176 NEWS | 14 March 2020 공항의 검사가 소용없다는 연구결과가 나오다. Airport screening is largely futile, research shows By Dennis Normile https://science.sciencemag.org/content/367/6483/1177 PERSPECTIVES AND COMMENTARY | 14 March 2020 nCoV 삼량체 스파이크의 구조 Structure of the nCoV trimeric spike By Michael Funk, et al. https://science.sciencemag.org/content/367/6483/1207.3 RESEARCH AND REVIEWS | 14 March 2020 예비 융합 형태에서 2019-nCoV 스파이크의 Cryo-EM 구조 Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation By Daniel Wrapp, et al. https://science.sciencemag.org/content/367/6483/1260 Fig. 1 Structure of 2019-nCoV S in the prefusion conformation.
(A) Schematic of 2019-nCoV S primary structure colored by domain. Domains that were excluded from the ectodomain expression construct or could not be visualized in the final map are colored white. SS, signal sequence; S2′, S2′ protease cleavage site; FP, fusion peptide; HR1, heptad repeat 1; CH, central helix; CD, connector domain; HR2, heptad repeat 2; TM, transmembrane domain; CT, cytoplasmic tail. Arrows denote protease cleavage sites. (B) Side and top views of the prefusion structure of the 2019-nCoV S protein with a single RBD in the up conformation. The two RBD down protomers are shown as cryo-EM density in either white or gray and the RBD up protomer is shown in ribbons colored corresponding to the schematic in (A). Fig. 2 Structural comparison between 2019-nCoV S and SARS-CoV S.
(A) Single protomer of 2019-nCoV S with the RBD in the down conformation (left) is shown in ribbons colored according to Fig. 1. A protomer of 2019-nCoV S in the RBD up conformation is shown (center) next to a protomer of SARS-CoV S in the RBD up conformation (right), displayed as ribbons and colored white (PDB ID: 6CRZ). (B) RBDs of 2019-nCoV and SARS-CoV aligned based on the position of the adjacent NTD from the neighboring protomer. The 2019-nCoV RBD is colored green and the SARS-CoV RBD is colored white. The 2019-nCoV NTD is colored blue. (C) Structural domains from 2019-nCoV S have been aligned to their counterparts from SARS-CoV S as follows: NTD (top left), RBD (top right), SD1 and SD2 (bottom left), and S2 (bottom right). Fig. 3 2019-nCoV S binds human ACE2 with high affinity.
(A) Surface plasmon resonance sensorgram showing the binding kinetics for human ACE2 and immobilized 2019-nCoV S. Data are shown as black lines, and the best fit of the data to a 1:1 binding model is shown in red. (B) Negative-stain EM 2D class averages of 2019-nCoV S bound by ACE2. Averages have been rotated so that ACE2 is positioned above the 2019-nCoV S protein with respect to the viral membrane. A diagram depicting the ACE2-bound 2019-nCoV S protein is shown (right) with ACE2 in blue and S protein protomers colored tan, pink, and green. Fig. 4 Antigenicity of the 2019-nCoV RBD.
(A) SARS-CoV RBD shown as a white molecular surface (PDB ID: 2AJF), with residues that vary in the 2019-nCoV RBD colored red. The ACE2-binding site is outlined with a black dashed line. (B) Biolayer interferometry sensorgram showing binding to ACE2 by the 2019-nCoV RBD-SD1. Binding data are shown as a black line, and the best fit of the data to a 1:1 binding model is shown in red. (C) Biolayer interferometry to measure cross-reactivity of the SARS-CoV RBD-directed antibodies S230, m396, and 80R. Sensor tips with immobilized antibodies were dipped into wells containing 2019-nCoV RBD-SD1, and the resulting data are shown as a black line. NEWS | 14 March 2020 시약이 미국 코로나바이러스 환자들에게 효과적이었나? Did an experimental drug help a U.S. coronavirus patient? By Jon Cohen https://www.sciencemag.org/news/2020/03/did-experimental-drug-help-us-coronavirus-patient PERSPECTIVES AND COMMENTARY | 12 March 2020 신종 코로나바이러스 발생: 팬데믹을 방지하기 위한 구상 New coronavirus outbreak: Framing questions for pandemic prevention By Scott P. Layne, et al. https://stm.sciencemag.org/content/12/534/eabb1469 NEWS | 11 March 2020 ‘우리는 뒤쳐졌다.’ 미국 병원들이 코로나바이러스 시험에 맞서다. ‘We're behind the curve’: U.S. hospitals confront the challenges of large-scale coronavirus testing By Jon Cohen NEWS | 11 March 2020 학교를 폐쇄하면 코로나바이러스 확산 방지을 느리게 할 수 있나? 과거에서 단서 제공 Does closing schools slow the spread of coronavirus? Past outbreaks provide clues By Jennifer Couzin-Frankel https://www.sciencemag.org/news/2020/03/does-closing-schools-slow-spread-novel-coronavirus NEWS | 10 March 2020 돌연변이는 코로나바이러스가 어떻게 움직이는지 보여줄 수 있지만 확대해석하기 쉽다. Mutations can reveal how the coronavirus moves—but they’re easy to overinterpret By Kai Kupferschmidt BLOGS | 10 March 2020 Covid-19 생물학적 치료 요법 검토 Covid-19 Biologic Therapies Reviewed By Derek Lowe https://blogs.sciencemag.org/pipeline/archives/2020/03/09/covid-19-biologic-therapies-reviewed NEWS | 7 March 2020 중국의 COVID-19 전략은 다른 곳에서도 통할까? Can China's COVID-19 strategy work elsewhere? By Kai Kupferschmidt, et al. https://science.sciencemag.org/content/367/6482/1061 NEWS | 7 March 2020 왜 공항의 검사로 코로나바이러스의 확산을 막을 수 없는가 Why airport screening won’t stop the spread of coronavirus By Dennis Normile https://www.sciencemag.org/news/2020/03/why-airport-screening-wont-stop-spread-coronavirus BLOGS | 6 March 2020 Covid-19 소분자 치료 요법 검토 Covid-19 Small Molecule Therapies Reviewed By Derek Lowe https://blogs.sciencemag.org/pipeline/archives/2020/03/06/covid-19-small-molecule-therapies-reviewed SITE INFORMATION AND HELP | 5 March 2020 코로나바이러스: 연구, 비평 및 뉴스 Coronavirus: Research, Commentary, and News https://www.sciencemag.org/coronavirus-research-commentary-and-news BLOGS | 5 March 2020 현실이다 Get Real By Derek Lowe https://blogs.sciencemag.org/pipeline/archives/2020/03/04/get-real
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