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| SCIENCE에 실린 코로나19 (COVID-19) 아티클 소개 (~3/31) |
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NEWS | Mar 29th, 2020 이란, '과학과 음모론 간의 싸움'속에 코로나바이러스에 맞서다. Iran confronts coronavirus amid a ‘battle between science and conspiracy theories’ By Richard Stone NEWS | Mar 28th, 2020 모든 사람들이 마스크를 쓰면 팬데믹을 늦추는데 도움을 줄까? Would everyone wearing face masks help us slow the pandemic? By Kelly Servick https://www.sciencemag.org/news/2020/03/would-everyone-wearing-face-masks-help-us-slow-pandemic NEWS | Mar 28th, 2020 중국 최고 과학자는 코로나바이러스 보호를 위해 마스크를 착용하지 않는 것은 '큰 실수'라고 말한다. Not wearing masks to protect against coronavirus is a ‘big mistake,’ top Chinese scientist says By Jon Cohen NEWS | Mar 28th, 2020 신종 코로나바이러스는 임산부에게 고통스러운 선택을 하게한다. 그러나 그것에 대한 데이터가 거의 없다. New coronavirus leaves pregnant women with wrenching choices—but little data to guide them By Gretchen Vogel NEWS | Mar 28th, 2020 코로나바이러스가 얼마나 당신을 아프게 할까? 그 답은 아마도 당신의 유전자에 있을 것이다. How sick will the coronavirus make you? The answer may be in your genes By Jocelyn Kaiser https://www.sciencemag.org/news/2020/03/how-sick-will-coronavirus-make-you-answer-may-be-your-genes PERSPECTIVES AND COMMENTARY | Mar 28th, 2020 덜 약속하고 더 해주어라! (과학에 대한 기대치는 낮추고 성과는 짭잘하게) Underpromise and Overdeliver By H. Holden Thorp https://science.sciencemag.org/content/367/6485/1405 PERSPECTIVES AND COMMENTARY | Mar 28th, 2020 코로나19는 맨하탄 프로젝트가 필요하다. COVID-19 needs a Manhattan Project By Seth Berkley https://science.sciencemag.org/content/367/6485/1407 NEWS | Mar 28th, 2020 COVID-19 모델링 시뮬레이션은 삶과 죽음에서 중요성을 갖는다. With COVID-19, modeling takes on life and death importance By Martin Enserink, et al. https://science.sciencemag.org/content/367/6485/1414.2
GRAPHIC: IMPERIAL COLLEGE COVID-19 RESPONSE TEAM, ADAPTED BY C. BICKEL/SCIENCE PERSPECTIVES AND COMMENTARY | Mar 28th, 2020 COVID-19에 대한 잘못된 약물 주의사항 Misguided drug advice for COVID-19 By Garret A. FitzGerald https://science.sciencemag.org/content/367/6485/1434.1 PERSPECTIVES AND COMMENTARY | Mar 28th, 2020 SARS-CoV-2가 사람 세포와 결합하는 방법 How SARS-CoV-2 binds to human cells By Michael Funk, et al. https://science.sciencemag.org/content/367/6485/1438.4 RESEARCH AND REVIEWS | Mar 28th, 2020 전장 사람 ACE2에 의한 SARS-CoV-2의 인식에 관한 구조적 기반 Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2 세포 속으로 침투하기 위한 첫 단계로 코로나바이러스는 표면에 위치한 스파이크단백질을 이용해 숙주세포의 수용체와 결합한다. 2019-nCoV와 사스바이러스는 ACE2를 수용체로 활용한다. By Renhong Yan, et al. https://science.sciencemag.org/content/367/6485/1444 Fig. 1 Overall structure of the ACE2-B0AT1 complex.
(A) Representative size exclusion chromatography purification profile of full-length human ACE2 in complex with B0AT1. UV, ultraviolet; mAU, milli–absorbance units; MWM, molecular weight marker. (B) Cryo-EM map of the ACE2-B0AT1 complex. The map is generated by merging the focused refined maps shown in fig. S2. Protomer A of ACE2 (cyan), protomer B of ACE2 (blue), protomer A of B0AT1 (pink) and protomer B of B0AT1 (gray) are shown. (C) Cartoon representation of the atomic model of the ACE2-B0AT1 complex. The glycosylation moieties are shown as sticks. The complex is colored by subunits, with the PD and CLD in one ACE2 protomer colored cyan and blue, respectively. (D) An open conformation of the ACE2-B0AT1 complex. The two PDs, which contact each other in the closed conformation, are separated in the open conformation. Fig. 2 Dimerization interface of ACE2.
(A) ACE2 dimerizes through two interfaces, the PD and the neck domain. The regions enclosed by the cyan and red dashed lines are illustrated in detail in (B) and (C), respectively. (B) The primary dimeric interface is through the neck domain in ACE2. Polar interactions are represented by red dashed lines. (C) A weaker interface between PDs of ACE2. The only interaction is between Gln139 and Gln175′, which are highlighted as spheres. The polar residues that may contribute to the stabilization of Gln139 are shown as sticks. (D) The PDs no longer contact each other in the open state. Single-letter abbreviations for the amino acid residues used in the figures are as follows: C, Cys; D, Asp; E, Glu; F, Phe; H, His; K, Lys; L, Leu; M, Met; N, Asn; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; and Y, Tyr. Fig. 3 Overall structure of the RBD-ACE2-B0AT1 complex.
(A) Cryo-EM map of the RBD-ACE2-B0AT1 complex. The overall reconstruction of the ternary complex at 2.9 Å is shown on the left. The inset shows the focused refined map of RBD. The color scheme is the same as that in Fig. 1B, with the addition of red and gold, which represent RBD protomers. (B) Overall structure of the RBD-ACE2-B0AT1 complex. The color scheme is the same as that in Fig. 1C. The glycosylation moieties are shown as sticks. Fig. 4 Interactions between SARS-CoV-2-RBD and ACE2.
(A) The PD of ACE2 mainly engages the α1 helix in the recognition of the RBD. The α2 helix and the linker between β3 and β4 also contribute to the interaction. Only one RBD-ACE2 is shown. (B to D) Detailed analysis of the interface between SARS-CoV-2-RBD and ACE2. Polar interactions are indicated by red dashed lines. NAG, N-acetylglucosamine. Fig. 5 Interface comparison between SARS-CoV-2-RBD and SARS-CoV-RBD with ACE2.
(A) Structural alignment for the SARS-CoV-2-RBD and SARS-CoV-RBD. The structure of the ACE2-PD and the SARS-CoV-RBD complex (PDB 2AJF) is superimposed on our cryo-EM structure of the ternary complex relative to the RBDs. The regions enclosed by the purple, blue, and red dashed lines are illustrated in detail in (B) to (D), respectively. SARS-CoV-2-RBD and the PD in our cryo-EM structure are colored orange and cyan, respectively; SARS-CoV-RBD and its complexed PD are colored green and gold, respectively. (B to D) Variation of the interface residues between SARS-CoV-2-RBD (labeled in brown) and SARS-CoV-RBD (labeled in green). NEWS | Mar 28th, 2020 COVID-19 치료제를 찾기 위한 경쟁에 가속도가 붙다. Race to find COVID-19 treatments accelerates By Kai Kupferschmidt, et al. https://science.sciencemag.org/content/367/6485/1412 NEWS | Mar 27th, 2020 미국은 COVID-19 연구의 패스트트랙을 위해 미국국립과학재단 (National Science Foundation, NSF)의 Rapid Response Research (RAPID) 프로그램을 활성화한다. Congress pumps up NSF program to fast-track COVID-19 research By Jeffrey Mervis https://www.sciencemag.org/news/2020/03/congress-pumps-nsf-program-fast-track-covid-19-research NEWS | Mar 27th, 2020 ‘이건 미친 짓이야!’ 많은 과학자들이 코로나바이러스에 말라리아 치료제를 쓰는 위험한 트럼프의방침에 탄식하고 있다. ‘This is insane!’ Many scientists lament Trump’s embrace of risky malaria drugs for coronavirus NEWS | Mar 26th, 2020 신종 코로나바이러스 러시아에서 발병. 러시아는 준비되었나? The new coronavirus is finally slamming Russia. Is the country ready? By Richard Stone https://www.sciencemag.org/news/2020/03/new-coronavirus-finally-slamming-russia-country-ready NEWS | Mar 26th, 2020 삶과 죽음의 수학: 어떤 질병 모델이 국가 봉쇄와 다른 팬데믹 정책을 만드는가? Mathematics of life and death: How disease models shape national shutdowns and other pandemic policies By Martin Enserink, et al. NEWS | Mar 26th, 2020 미국은 코로나19의 막대한 영향으로 경기 부양책에 연구비와 대학 지원을 포함한다. Massive U.S. coronavirus stimulus includes research dollars and some aid to universities By Jeffrey Mervis BLOGS | Mar 24th, 2020 최신 코로나바이러스 임상시험 The Latest Coronavirus Clinical Trials By Derek Lowe https://blogs.sciencemag.org/pipeline/archives/2020/03/24/the-latest-coronavirus-clinical-trials
NEWS | Mar 23rd, 2020 100년 된 결핵 백신이 신종 코로나바이러스에 대항해 면역 체계를 강화할 수 있을까? Can a century-old TB vaccine steel the immune system against the new coronavirus? By Jop de Vrieze NEWS | Mar 23rd, 2020 WHO는 코로나바이러스의 가장 유망한 4가지 치료법을 전 세계적으로 시행한다고 밝혔다. WHO launches global megatrial of the four most promising coronavirus treatments 1) Remdesivir 렘데시비르 2) Chloroquine and hydroxychloroquine 클로로퀸 및 하이드록시클로로퀸 Lines of attack Experimental treatment strategies being tested by a large WHO study and other clinical trials attempt to interfere with different steps (numbered) in the coronavirus replication cycle.
3) Ritonavir/lopinavir 리토나비르 로피나비르 혼합제 4) Ritonavir/lopinavir and interferon-beta 리토나비르 로피나비르 혼합제에 인터페론 베타 추가 By Kai Kupferschmidt, et al. NEWS | Mar 23rd, 2020 표준 코로나바이러스 진단법을 잘 시행하고 있지만, 팬데믹 상황에서 새로운 진단법이 도움될까? The standard coronavirus test, if available, works well—but can new diagnostics help in this pandemic? By Robert F. Service PERSPECTIVES AND COMMENTARY | Mar 21st, 2020 함께 할 시간이 되었다! Time to pull together By H. Holden Thorp https://science.sciencemag.org/content/367/6484/1282 NEWS | Mar 21st, 2020 코로나19에 대한 전쟁에서 국가들의 진단 전략 Countries test tactics in ‘war’ against COVID-19 By Jon Cohen, et al. https://science.sciencemag.org/content/367/6484/1287 NEWS | Mar 21st, 2020 코로나바이러스의 혼란은 많은 연구를 중단시켰다. Coronavirus disruptions reverberate through research By Kelly Servick, et al. https://science.sciencemag.org/content/367/6484/1289 PERSPECTIVES AND COMMENTARY | Mar 21st, 2020 학계의 코로나19 편견 예방 Preventing COVID-19 prejudice in academia By Piotr Rzymski, et al. https://science.sciencemag.org/content/367/6484/1313.1 NEWS | Mar 21st, 2020 아프고 힘든 나날 Sick time By Jon Cohen https://science.sciencemag.org/content/367/6484/1294
CAREERS AND CAREER RESOURCES | Mar 21st, 2020 코로나바이러스로 인한 폐쇄에서, 일부 대학원생은 실험실에 보고해야 하는 압박을 느낀다. Amid coronavirus shutdowns, some grad students feel pressure to report to their labs By Michael Price NEWS | Mar 20th, 2020 항체에 대한 새로운 혈액 검사로 정확한 규모의 코로나바이러스 팬데믹을 나타낸다. New blood tests for antibodies could show true scale of coronavirus pandemic By Gretchen Vogel BLOGS | Mar 20th, 2020 코로나바이러스: 임상시험 데이터 Coronavirus: Some Clinical Trial Data By Derek Lowe https://blogs.sciencemag.org/pipeline/archives/2020/03/19/coronavirus-some-clinical-trial-data
The results are shown at Figure. As you can see, there appears to be an effect of hydroxychloroquine (although I would like to see some error bars), and a notably stronger effect (down to zero virus as measured by nasal swab) of the hydroxychloroquine – azithromycin combination. That’s the result that’s getting the attention, and justifiably so. PERSPECTIVES AND COMMENTARY | Mar 19th, 2020 COVID-19 방역: 공공 보건 및 전염병 관리에서 로봇공학의 역할 Combating COVID-19: The role of robotics in managing public health and infectious diseases By Guang-Zhong Yang, et al. https://robotics.sciencemag.org/content/5/40/eabb5589 NEWS | Mar 19th, 2020 대량 검사, 학교 폐쇄, 락다운 (이동제한령) : 각국은 코로나바이러스와의 전쟁에서 전략 선택 Mass testing, school closings, lockdowns: Countries pick tactics in ‘war’ against coronavirus By Jon Cohen, et al. 급격한 증가 (Exponential growth) China’s outbreak has come to a halt and South Korea has flattened its curve, but COVID-19 case numbers are still rising rapidly in many Western countries.
ONE WORLD IN DATA; JOHNS HOPKINS UNIVERSITY/CSSE NEWS | Mar 19th, 2020 인공호흡기, 검역소 및 최악의 시나리오: 동물 실험실, 팬데믹 문제로 고심하다 Respirators, quarantines, and worst-case scenarios: Lab animal facilities grapple with the pandemic By David Grimm |
