KMCRIC

1.
[Interaction]
When Gamisoyosan and Tamoxifen were administered in mouse models implanted with breast cancer cell line MCF-7, Tamoxifen's inhibitory effect on cancer cell growth and autophagy signaling was maintained [​3​].

[Expert interpretation]
Gamisoyosan does not affect the anticancer efficacy of Tamoxifen.

2.
[Interaction]
When Gamisoyosan and Tamoxifen were treated in breast cancer cell line MCF-7, Tamoxifen's cytotoxicity and efficacy on autophagy signaling were maintained [​3​].

[Expert interpretation]
Gamisoyosan does not affect the anticancer efficacy of Tamoxifen.

3.
[Interaction]
When administered to a normal rat model with gamisoyosan and tamoxifen, gamisoyosan did not affect the plasma absorption rate (AUC, Cmax, Tmax) or half-life (T1/2) of tamoxifen [​4​].

[Expert interpretation]
Gamisoyosan did not affect the blood concentration of tamoxifen.

... Co, Ltd. (물 추출물)
Treatment: 1, 3 ug/ml

[양약투여조건]
Material: AstraZeneca UK Limited.
Treatment: 2.5, 5 ug/ml. 가미소요산 처리 30분 뒤 투여 및 24시간 처리

[투여그룹]
1) Tamoxifen 단독 처리
2) Tamoxifen + 가미소요산 처리

3.
...

[Interaction]
In mice with acetaminophen-induced liver damage, administration of gamisoyosan significantly reduced plasma ALT and AST levels, and significantly increased hepatoprotective factors (SOD, Catalase, GPx, GR, and GST) [​6​].

[Expert interpretation]
Gamisoyosan may protect against acetaminophen-induced liver damage.

..., 1400 mg/kg. 1회/1일/7일. 경구 투여

[양약투여조건]
Material: Sigma Aldrich
Treatment: 200 mg/kg. 1회/1일. 복강 투여. 가미소요산 마지막 투여 6시간 뒤 처리

[투여그룹]
1) Acetaminophen 단독 처리
2) Acetaminophen + 가미소요산 700 처리...