KMCRIC

고희재 박사 Jade Heejae Ko, Ph.D.

스탠포드의대 신경외과 스타인버그연구소

Gary K. Steinberg Lab, Department of Neurosurgery, Stanford School of Medicine, USA 

email: hjaeko@stanford.edu

00:00:17 Q1. 자기 소개

00:00:50 Q2. 최신 연구 소개

00:05:52 Q3. 연구할 때 제일 보람있는 순간은?

00:07:04 Q4. 현재 소속 연구실 소개

00:07:56 Q5. 후배들에게 남기고 싶은 말

[A representative study]

Ko JH, Lee H, Kim SN, Park HJ. Does Acupuncture Protect Dopamine Neurons in Parkinson's Disease Rodent Model?: A Systematic Review and Meta-Analysis. Front Aging Neurosci. 2019 May 8;11:102. doi: 10.3389/fnagi.2019.00102.

[Abstract]

Background: Acupuncture has been reported to have significant effects, not only in alleviating impaired motor function, but also rescuing dopaminergic neuron deficits in rodent models of Parkinson's disease (PD). However, a systemic analysis of these beneficial effects has yet to be performed. Objective: To evaluate the neuroprotective effect of acupuncture in animal models of PD. Methods: A literature search of the PubMed, MEDLINE, EMBASE, China National Knowledge Infrastructure, Research Information Service System, and Japan Society of Acupuncture and Moxibustion databases was performed to retrieve studies that investigated the effects of acupuncture on PD. The quality of each included study was evaluated using the 10-item checklist modified from the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies. RevMan version 5.3 (Foundation for Statistical Computing, Vienna, Austria) was used for meta-analysis. Results: The 42 studies included scored between 2 and 7 points, with a mean score of 4.6. Outcome measures included tyrosine hydroxylase (TH) level and dopamine content. Meta-analysis results revealed statistically significant effects of acupuncture for increasing both TH levels (33.97 [95% CI 33.15-34.79]; p < 0.00001) and dopamine content (4.23 [95% CI 3.53-4.92]; p < 0.00001) compared with that observed in PD control groups. In addition, motor dysfunctions exhibited by model PD animals were also mitigated by acupuncture treatment. Conclusions: Although there were limitations in the number and quality of the included studies, results of this analysis suggest that acupuncture exerts a protective effect on dopaminergic neurons in rodent models of PD.

Keywords: Parkinson's disease; acupuncture; dopamine neuroprotection; meta analysis; rodent model; systematic review.

[A brief introduction]

저는 파킨슨병과 염증성 뇌 질환 및 기타 염증성 질환에서의 침 치료 효과를 알아보는 한의학적 치료를 중심으로 연구를 수행해 왔습니다. 특히 침 치료가 효과를 나타내는 기전을 알아보기 위한 방법으로 혈액 또는 뇌의 특정 부위에서 유의미하게 발현되는 microRNA의 변화에 집중하였고,  이러한 주제로 최근 5년간 다수의 논문을 국내외 저널에 게재하였습니다.

현대의 최신 의공학 및 융합기술을 이용한 신경회로 조절 및 신경세포 간의 네트워킹 분석을 통해 뇌 질환 및 신경정신 질환 발병의 원인과 치료 방법 연구에 큰 관심을 가지고 있습니다. 현재는 광유전학적 방법을 이용한 뇌졸중 발병 기전 및 치료법에 관한 연구를 수행하고 있습니다.

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