연구자 인터뷰
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서수연 박사 Su Yeon Seo (Adjunct Professor)
한국한의학연구원 한의과학연구부 Korean Convergence Medical Science, University of Science & Technology, KIOM, Daejeon, South Korea email: ssy1025@kiom.re.kr
00:00:17 Q1. 자기 소개 00:02:04 Q2. 최신 연구 소개 00:09:09 Q3. 연구할 때 제일 보람있는 순간은? 00:09:49 Q4. 현재 소속 연구실 소개 00:10:29 Q5. 후배들에게 남기고 싶은 말
[Research Interests]
1. Neuromodulation 2. Signal transmission mechanism of acupuncture stimulation 3. Neurophysiology of drug addiction and emotional disorderss 4. Emotional disorders and drug addiction non-pharmacological management techniques 5. Neurotransmitter homeostasis control mechanism of acupuncture stimulation
[A representative study]
[Abstract]
Activation of protein kinases after cocaine administration controls psychomotor behaviours by interacting with metabotropic receptors in the brain. This study identified how c-Jun N-terminal kinase (JNK) interacts with metabotropic glutamate receptor 5 (mGluR5) in vitro and in the caudate and putamen (CPu). The potential role of this interaction in the regulation of psychomotor behaviour was also evaluated after administration of cocaine. Active JNK phosphorylates a threonine residue at position 1055 in the carboxyl terminus (CT) of mGluR5 in vitro. The binding of active JNK to the D-motif within CT2 is necessary for that phosphorylation. Interaction of phosphorylated JNK and mGluR5 occurs in the CPu. Unilateral interference of the interaction decreases the repeated cocaine-induced increases in locomotor activity and conditioned place preference. These findings suggest that activation of JNK has the capability to interact with mGluR5 in the CPu. Phosphorylation of mGluR5 following the JNK-mGluR5 interaction may be responsible for the potentiation of behavioural sensitisation and cocaine-wanting behaviour in response to cocaine administration. Keywords: conditioned place preference; group I mGluR; protein kinase
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