KMCRIC

Diabetes and obesity-related complications and associated metabolic disorders are major public health problems at the local, national and global levels. These metabolic defects underlie the basis for multiple debilitating diseases including heart disease, stroke, blindness, kidney disease, hypertension, neural degeneration, wound healing, amputations, periodontal disease and birth defects. This meeting will address several cutting-edge aspects of molecular, cellular, tissue and integrative system metabolism that account for the metabolic defects that occur in diabetes and obesity. Several of these themes overlap with the concurrent meeting on Mitochondria, Metabolism and Heart Failure and four concurrent sessions are planned addressing distinct and novel aspects of normal and dysregulation muscle (skeletal and cardiac) intracellular signaling, mitochondria function/dynamics, aging and energy balance. Leaders in each of these respective areas will not only address basic and integrative mechanisms in model systems, but several will address these issues in human pathology.