KMCRIC

In human study, a combination of piperine and curcumin resulted in a reduction in erythrocyte malondialdehyde levels in patients with tropical pancreatitis [​105​]. Piperine acts as a bioavailability enhancer for curcumin, but bioavailability is not as good as that seen with curcumin encapsulated in nanoparticles [​106​]. Addition of piperine to curcumin for efficacy study in animal models suggests piperine increases its absorption and efficacy in some [​107​;​108​;​109​], but not all [​110​] studies. According to a review, piperine might increase curcumin bioavailability by interfering with glucuronidation [​111​].

임상 연구에서, 피페린과 커큐민의 조합은 열대성 췌장염(tropical pancreatitis) 환자에게서 적혈구 말론디알데히드(erythrocyte malondialdehyde)의 감소를 초래하였다 [​105​]. 피페린은 커큐민을 위한 생체이용률 증강인자로서...

In human study, a combination of piperine and curcumin resulted in a reduction in erythrocyte malondialdehyde levels in patients with tropical pancreatitis [​98​]. Piperine acted as a bioavailability enhancer for curcumin, but bioavailability was not as good as that seen with curcumin encapsulated in nanoparticles [​99​]. Addition of piperine to curcumin for efficacy study in animal models suggested piperine increased its absorption and efficacy in some [​100​;​101​;​102​] but not all [​103​] studies. According to a review, piperine might increase curcumin bioavailability by interfering with glucuronidation [​104​].

동물과 시험관 연구에서, 피페린과 dipiperamides D와 E를 포함한, 후추등으로부터 분리된 추출물과 구성성분은, CYP2D6 [​49​;​50​;​51​], CYP3A4 [​43​;​51​;​52​;​53​], CYP2B1 [​54​;​55​], CYP1A1 [​56​], CYP2E1 [​57​], 아릴기탄화수소 수산화효소와 7-에톡실기...

Combined administration with curcumin, a biphenyl compound derived from rhizome of Curcuma longa, and emodin, an active component isolated from Rheum palmatum, synergistically inhibits proliferation, survival, and invasion of breast cancer cells by downregulating Bcl-2 and Bmi-1.

대황 (Rheum palmatum)에서 분리된 emodin과 강황 (Curcuma longa)에서 분리된 curcumin의 동시 투여는 Bcl-2와 Bmi-1을 줄이는 기전으로 유방암 세포의 확산, 생존, 침입을 억제하는 시너지 효과가 확인됨.

CPZ consisting extracts of Chrysanthemum indicum, Patchouli Oil and Zedoary Turmeric Oil possessed anti-inflammatory activity via regulation on IL-1β and PGE(2) in dimethylbenzene (DMB)-induced ear vasodilatation and acetic acid-induced capillary permeability enhancement mice model, as well...

... (Chrysanthemum indicum), 패출리유 (Patchouli Oil), 봉술 강황유 (Zedoary Turmeric Oil) 추출물로 구성된 CPZ는 carrageenan 유도 흰쥐 발 부종 모델 뿐 아니라 dimethylbenzene 유도 귀 혈관 확장 및 아세트산 유도 모세혈관 투과성 증가 생쥐...