KMCRIC

[Interaction]
In an open-label, randomized, three-period, two-sequence trial in 14 healthy Korean adults, co-administration of BBCT reduced the Cmax of atorvastatin by 24% (21.2 -> 17.7 ng/mL), while AUClast and AUCinf were statistically equivalent to atorvastatin alone. For the active metabolite 2-hydroxy atorvastatin, BBCT reduced Cmax by 30.2%, AUClast by 14.9% and AUCinf by 14.8%. 4-hydroxy atorvastatin was largely unaffected [2].

[Expert interpretation]
BBCT weakly reduces systemic exposure to Atorvastatin and its active metabolite 2-hydroxy atorvastatin by decreasing the absorption of Atorvastatin, so careful monitoring may be warranted during concomitant use.

.... aPTT 및 PT 기반 약력학 지표 (AUEC, Rmax)는 병용 여부와 무관하게 동등하였음 [2].

[해석]
반하백출천마탕은 에독사반 (Edoxaban)의 흡수 속도 감소를 통해 최고 혈중 농도만 낮출 뿐 총 노출량 및 항응고 약력학에는...

[Interaction]
In an open-label, randomized, three-period, two-sequence trial in 14 healthy Korean adults, co-administration of BBCT reduced the Cmax of atorvastatin by 24% (21.2 -> 17.7 ng/mL), while AUClast and AUCinf were statistically equivalent to atorvastatin alone. For the active metabolite 2-hydroxy atorvastatin, BBCT reduced Cmax by 30.2%, AUClast by 14.9% and AUCinf by 14.8%. 4-hydroxy atorvastatin was largely unaffected [1].

[Expert interpretation]
BBCT weakly reduces systemic exposure to Atorvastatin and its active metabolite 2-hydroxy atorvastatin by decreasing the absorption of Atorvastatin, so careful monitoring may be warranted during concomitant use.

... Cmax 30.2%, AUClast 14.9%, AUCinf 14.8% 감소하였고, 4-hydroxy atorvastatin은 뚜렷한 변화가 없었음 [1].

[해석]
반하백출천마탕은 아토르바스타틴 (Atorvastatin)의 흡수 감소를 통해 Atorvastatin 및 활성대사체 2-hydroxy atorvastatin의 전신...

Both crude and acidic polysaccharide extracts from Gastrodia rhizomes inhibited the total cholesterol and LDL levels in Sprague Dawley(SD) rats fed a high-fat diet. There was a significantly suppressed atherosclerosis risk(atherogenic index) due to the acidic polysaccharide extract(of total...

... 및 천마의 산성 다당체 추출물은 고지방 식이 흰쥐 고지혈증 모델에서 총 콜레스테롤과 LDL 수치를 감소시킴. 그 중 천마의 산성 다당체 추출물은 동맥경화의 위험을 매우 감소시켜 천마의 고지혈증, 동맥경화에 대한...

After the Tianma treatment of 2.5 g/kg body weight over 7 weeks to rat, contractility was measured in detrusor strips isolated in both transverse (Tr) and longitudinal (Lg) directions with the urothelium intact (+UE) or denuded (-UE). Spontaneous phasic activity was enhanced in longitudinal ...

... 스트립에서 자발적 수축 운동이 증가함. K+-Kerbs의 용액 또는 carbachol에 의해 유도된 수축성은 대조군과 천마 투여 실험군 간에서 차이를 보이지 않음. 또한, 천마 투여는 -UE strip에서 Isoprenaline이 유도한 이완을...