KMCRIC

In laboratory research and animals, ginseng preparations acted synergistically with cytotoxic drugs, chemotherapy, and radiation [30;​76​;​77​;​78​]. In theory, their effectiveness may be increased when multiple agents are used in optimal combinations. Antineoplastic effects of ginseng and ginsenosides have been found in vitro and in vivo [​79​;​80​;​81​;​82​;​83​;​84​;​85​;​86​;​87​;​88​;​89​;​90​;​91​;​92​;​93​]. In animals, Korean red ginseng may interact synergistically with paclitaxel and attenuate cisplatin-induced nausea and vomiting [​54​;​78​]. In vitro, a combination of American ginseng berry extract (AGBE) or Asian ginseng and 5-fluorouracil (5-FU) decreased cell growth in human colorectal cancer cell lines more than when either was used alone [​94​;​95​]. Similar effects were observed for ginseng neutral polysaccharides and 5-FU in sarcoma-180 (S180) tumor-bearing mice [​96​]. In vitro, ginseng and doxorubicin treatment of a doxorubicin-resistant human breast cancer cell line downregulated the multidrug resistance1 (MDR1) protein [​97​]. In vitro, panaxytriol from Panax ginseng acted synergistically with mitomycin C [​98​]. In vitro, KG-135, a quality-controlled standardized ginsenoside formulation, potentiated etoposide-induced apoptosis in HeLa cells [​99​]. In animals, Korean red ginseng total extract significantly attenuated cisplatin-induced nausea and vomiting when administered 1-2 hours before cisplatin [​54​]. Korean red ginseng also inhibited cisplatin-induced oxidation and apoptosis in vitro in an auditory cell line [​100​]. In a case study, coadministration of imatinib and a ginseng energy drink resulted in right upper-quadrant pain and increased liver enzyme levels [​101​]. The patient's only lifestyle change was daily ingestion of Panax ginseng via energy drinks for the previous three months. Both imatinib and ginseng were discontinued, and the patient was treated with a short course of corticosteroids. Imatinib was later restarted at the same dose, with no recurrent elevations in his liver enzyme levels. The potential for interactions with anticancer agents of herbal products, including ginseng, has been reviewed [​102​].

... 공식명칭)는 에토포시스로 유도된 헬라세포의 세포자멸사 효과를 증가시켰다 [​99​]. 동물의 경우, 한국 홍삼 총 추출물을 시스플란틴 사용 1-2시간전에 투여하자 시스플란틴 투약으로 발생하는 구역, 구토를 눈에 띄게...

In vitro, ginseng saponins, especially the panaxatriol saponin fraction, had substantial inhibitory effects on the recombinant serotonin type 3A receptor, suggesting that some specific ginsenosides might have an antagonistic action against serotonin type 3A receptor related to nausea and vomiting [​53​]. These antiemetic results are supported by an animal research using Korean red ginseng total extract [​54​].

... 것은, 몇몇의 특정한 진세노사이드 성분이 오심과 구토와 관련있는 세로토닌 3A형 수용체에 길항작용을 나타낸다는 것을 암시한다 [​53​]. 이러한 항구토작용 연구를 한국 홍삼 추출물을 사용한 동물 실험이 뒷받침한다 [​54​]....

fermented red ginseng extract (FRG) possesses enhanced anti-inflammatory and antinociceptive activity but similar anti-angiogenic activity than red ginseng extract (RG).

발효홍삼은 홍삼과 항혈관신생작용은 유사하지만 홍삼보다 항염증작용과 항통각작용은 뛰어남.

White ginseng (WG) and red ginseng (RG) showed antiasthmatic effects in an OVA-sensitized mouse model, and the efficacies of RG were found to be better than those of WG.

백삼과 홍삼추출물은 OVA 유도 천식마우스에 기도 민감성, 기관지 폐포액의 면역세포, cytokine의 감소를 유도하여 천식을 개선하며, 홍삼의 효능이 백삼보다 우수하였음.