KMCRIC

1.
[Interaction]
When Gamisoyosan and Tamoxifen were administered in mouse models implanted with breast cancer cell line MCF-7, Tamoxifen's inhibitory effect on cancer cell growth and autophagy signaling was maintained [​9​].

[Expert interpretation]
Gamisoyosan does not affect the anticancer efficacy of Tamoxifen.

2.
[Interaction]
When Gamisoyosan and Tamoxifen were treated in breast cancer cell line MCF-7, Tamoxifen's cytotoxicity and efficacy on autophagy signaling were maintained [​9​].

[Expert interpretation]
Gamisoyosan does not affect the anticancer efficacy of Tamoxifen.

3.
[Interaction]
When administered to a normal rat model with gamisoyosan and tamoxifen, gamisoyosan did not affect the plasma absorption rate (AUC, Cmax, Tmax) or half-life (T1/2) of tamoxifen [​8​].

[Expert interpretation]
Gamisoyosan did not affect the blood concentration of tamoxifen.

... Co, Ltd. (물 추출물)
Treatment: 1, 3 ug/ml

[양약투여조건]
Material: AstraZeneca UK Limited.
Treatment: 2.5, 5 ug/ml. 가미소요산 처리 30분 뒤 투여 및 24시간 처리

[투여그룹]
1) Tamoxifen 단독 처리
2) Tamoxifen + 가미소요산 처리

3.
...

1.
[Interaction]
In male SD rats given a single oral dose of ondansetron (10 mg/kg) with Ijintang-gamibang (IJTGMB, 100 mg/kg) co-administered orally within 5 min, the plasma concentration profile of ondansetron did not differ from the control, and none of the pharmacokinetic parameters (Tmax, Cmax, AUC, t1/2, MRTinf) differed between the two treatments. The same was true for the initial dose of the repeated-dosing study after 6 days of IJTGMB pretreatment [​2​].

[Expert interpretation]
Ijintang-gamibang does not affect the pharmacokinetics of Ondansetron on single co-administration, as it alters neither the absorption nor the elimination of Ondansetron, with or without 6-day pretreatment.

2.
[Interaction]
After 8 days of repeated co-administration (following 6 days of IJTGMB pretreatment), plasma ondansetron was detected at lower concentrations and for a longer duration in the combination group than in the control. AUC0-t decreased from 460.82 +- 150.84 to 281.15 +- 60.21 ng*h/mL and AUC0-inf from 473.32 +- 164.17 to 291.54 +- 59.10 ng*h/mL (both p<0.05); Cmax fell from 327.60 +- 57.35 to 237.60 +- 72.96 ng/mL, while t1/2 (0.66 -> 0.78 h) and MRTinf (1.35 -> 1.33 h) were largely unchanged [​2​].

[Expert interpretation]
Repeated co-administration of Ijintang-gamibang significantly reduces the bioavailability of Ondansetron by interfering with its absorption while leaving t1/2 and MRTinf unchanged; the authors suggest separating the two by an interval longer than the MRTinf of Ondansetron.

...

[투여그룹]
6주령 수컷 SD 랫트 10마리 (Study I, 단회 투여)
1) Ondansetron + 증류수 (대조군)
2) Ondansetron + 이진탕가미방 (병용군)

2. 이진탕가미방-Ondansetron
[약물상호작용]
이진탕가미방 6일 전처치 후 8일간 반복 병용...