KMCRIC

1.
[Interaction]
When Gamisoyosan and Tamoxifen were administered in mouse models implanted with breast cancer cell line MCF-7, Tamoxifen's inhibitory effect on cancer cell growth and autophagy signaling was maintained [​3​].

[Expert interpretation]
Gamisoyosan does not affect the anticancer efficacy of Tamoxifen.

2.
[Interaction]
When Gamisoyosan and Tamoxifen were treated in breast cancer cell line MCF-7, Tamoxifen's cytotoxicity and efficacy on autophagy signaling were maintained [​3​].

[Expert interpretation]
Gamisoyosan does not affect the anticancer efficacy of Tamoxifen.

3.
[Interaction]
When administered to a normal rat model with gamisoyosan and tamoxifen, gamisoyosan did not affect the plasma absorption rate (AUC, Cmax, Tmax) or half-life (T1/2) of tamoxifen [​4​].

[Expert interpretation]
Gamisoyosan did not affect the blood concentration of tamoxifen.

... Co, Ltd. (물 추출물)
Treatment: 1, 3 ug/ml

[양약투여조건]
Material: AstraZeneca UK Limited.
Treatment: 2.5, 5 ug/ml. 가미소요산 처리 30분 뒤 투여 및 24시간 처리

[투여그룹]
1) Tamoxifen 단독 처리
2) Tamoxifen + 가미소요산 처리

3.
...

[Interaction]
When normal individuals took gamisoyosan and escitalopram, the plasma absorption rate (AUC, Cmax, Tmax) of escitalopram was not altered by gamisoyosan [​5​].

[Expert interpretation]
Gamisoyosan did not affect the blood concentration of escitalopram.

... 시, Escitalopram의 혈장 내 흡수율 (AUC, Cmax, Tmax)는 가미소요산에 의해 변화되지 않음 [​5​].

[전문가 해석]
가미소요산은 Escitalopram의 혈액 내 농도에 영향을 주지 않음.

[한약투여조건]
Material: Hanpoong Pharmaceutical Co, Ltd....