KMCRIC

Radix ginseng combined with radix Astragali showed better antioxidant activity when compared to radix ginseng alone [​183​].

황기와 배합한 인삼은 인삼 홀로 쓰일 때와 비교하여 더 나은 항산화 효과를 보여준다 [​183​].

Based on laboratory research, Panax ginseng may inhibit CYP2D6 [​123​]. In vitro, eight ginsenosides and aglycones potently induced CYP1A1 expression; deglycosylated ginsenosides were more potent inducers of CYP1A1, CYP1A2, and CYP3A4 than the glycosylated ginsenosides in HepG2 cells [​124​]. Although Panax ginseng has been shown to activate CYP3A4 in vitro, there is a lack of an in vivo correlation with the in vitro effects [​125​;​126​;​127​;​128​;​129​]. In vitro, Panax notoginseng saponins had a lack of an effect on testosterone metabolism in a test of CYP3A4 metabolism [​130​]. In rats, Panax notoginseng induced CYP3A1 mRNA and CYP1A1, but a lack of an effect was seen on CYP1B1 mRNA expression in lung tissue [​131​] or on the expression of CYP2B1 and CYP4A1 genes in liver tissues of rats [​132​]. Laboratory studies demonstrated a lack of an effect of ginseng preparations or Cold-fX® on CYP450 activity [​133​;​134​]. In vitro, nine ginseng products studied had little to no effect on the activity of CYP3A4 [​135​]. In rats, shenmai injection (SMI), a mixture of radix ginseng and radix Ophiopogonis, caused a rise in AUC for midazolam (CYP450 3A1/2) and an increase in AUC for diclofenac (CYP4502C6) [​136​]. The pharmacokinetics of chlorzoxazone (CYP4502E1) and theophylline (CYP4501A2) in rats was not altered markedly. In rat liver microsomes, linear mixed-type inhibition by SMI of the enzyme activities of CYP3A1/2, CYP2C6, and CYP1A2 was shown with IC50 values of 3.3%, 2.0%, and 3.1%, respectively, and Ki values of 3.8%, 1.5%, and 1.9%, respectively. However, the effects of ginseng alone are unclear. However, according to a systematic review of herbal drugs and pharmacokinetic drug interactions, of 66 studies identified, clinical evidence for ginseng was considered "limited" (a lack of potent or moderate inhibitory effect on cytochrome P450 or p-glycoprotein) [​137​].

... 연구들은 CYP450 의 활동에서 Cold-fX® 또는 인삼제제의 효능 부족을 증명했다 [​133​;​134​]. 시험관 연구에서 9종의 인삼 제품에 대한 연구는 CYP3A4의 활동에 어떠한 영향도 미치지 않았다 [​135​]. 쥐의 경우, 인삼과 맥문동의...

the saponin of heat-processed ginseng (Sun ginseng, SG) has the protective effect on chronic renal failure.

건조 인삼의 사포닌은 만성 신부전에 보호효과가 있음.

White ginseng (WG) and red ginseng (RG) showed antiasthmatic effects in an OVA-sensitized mouse model, and the efficacies of RG were found to be better than those of WG.

백삼과 홍삼추출물은 OVA 유도 천식마우스에 기도 민감성, 기관지 폐포액의 면역세포, cytokine의 감소를 유도하여 천식을 개선하며, 홍삼의 효능이 백삼보다 우수하였음.