KMCRIC

In laboratory research and animals, ginseng preparations acted synergistically with cytotoxic drugs, chemotherapy, and radiation [30;​76​;​77​;​78​]. In theory, their effectiveness may be increased when multiple agents are used in optimal combinations. Antineoplastic effects of ginseng and ginsenosides have been found in vitro and in vivo [​79​;​80​;​81​;​82​;​83​;​84​;​85​;​86​;​87​;​88​;​89​;​90​;​91​;​92​;​93​]. In animals, Korean red ginseng may interact synergistically with paclitaxel and attenuate cisplatin-induced nausea and vomiting [​54​;​78​]. In vitro, a combination of American ginseng berry extract (AGBE) or Asian ginseng and 5-fluorouracil (5-FU) decreased cell growth in human colorectal cancer cell lines more than when either was used alone [​94​;​95​]. Similar effects were observed for ginseng neutral polysaccharides and 5-FU in sarcoma-180 (S180) tumor-bearing mice [​96​]. In vitro, ginseng and doxorubicin treatment of a doxorubicin-resistant human breast cancer cell line downregulated the multidrug resistance1 (MDR1) protein [​97​]. In vitro, panaxytriol from Panax ginseng acted synergistically with mitomycin C [​98​]. In vitro, KG-135, a quality-controlled standardized ginsenoside formulation, potentiated etoposide-induced apoptosis in HeLa cells [​99​]. In animals, Korean red ginseng total extract significantly attenuated cisplatin-induced nausea and vomiting when administered 1-2 hours before cisplatin [​54​]. Korean red ginseng also inhibited cisplatin-induced oxidation and apoptosis in vitro in an auditory cell line [​100​]. In a case study, coadministration of imatinib and a ginseng energy drink resulted in right upper-quadrant pain and increased liver enzyme levels [​101​]. The patient's only lifestyle change was daily ingestion of Panax ginseng via energy drinks for the previous three months. Both imatinib and ginseng were discontinued, and the patient was treated with a short course of corticosteroids. Imatinib was later restarted at the same dose, with no recurrent elevations in his liver enzyme levels. The potential for interactions with anticancer agents of herbal products, including ginseng, has been reviewed [​102​].

실험연구와 동물에서, 인삼제제는 세포독성제, 화학요법, 방사능과 함께 쓸 때 상승효과를 일으켰다 [30;​76​;​77​;​78​]. 이론상으로 그러한 효과는 다양한 약물이 최적의 조합으로 사용되었을 때 일어난다. 인삼과...

In human research, dissolved licorice powder and mixed ingredient herbal diets and formulations containing licorice (e.g. Tsumura TJ-68, shakuyakukanzoto, shao-yao-gan-cao-tang) ameliorated pain associated with cancer, intubation, and muscle cramps [​14​;​15​;​16​;​17​;​18​].

임상 연구에서, 용해 감초 가루와 혼합 재료 한방 다이어트 그리고 감초를 함유한 정제(예를 들면, Tsumura TJ-68, shakuyakukanzoto, shao-yao-gan-cao-tang)는 종양, 기관삽관, 그리고 근육경련과 관련된 통증을 개선하였다 [​14​;​15​;​16​;​17​;​18​].

Intrathecal and oral administration of baicalein isolated from Scutellaria baicalensis could alleviate the mechanical allodynia in cancer-induced bone pain rats.

황금 (Scutellaria baicalensis) 성분 baicalein의 척수강 내 및 경구 투여는 cancer-induced bone pain 흰쥐 모델에서 물리적 이질통을 완화시킴.

... which subsequently down-regulated Mcl-1 protein and up-regulated Bax, while it had a minimal effect on Bcl-2 expression. Imperatorin sensitizes anoikis in other lung cancer cells, namely, H292 and A549. Because anoikis was shown to be a critical hindrance in preventing cancer cell metastasis.

Imperatorin은 p53 단백질 수준을 증가시킴으로써 Mcl-1 단백질을 하향 조정 및 Bax를 상향 조정함. Bcl-2 발현에는 미미한 영향을 미침. 또한, Imperatorin은 폐암 세포 H292 및 A549에서 암 전이 억제를 막는 anoikis에 민감하게 반응함.