전체보기 학술정보센터 (5)건 |
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[센터]
약리작용 등록-승마49 연교43 의이인72 지골피9 (173개) |
[센터]
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전체보기 한의약융합데이터센터 (137)건 | ||||
근거중심한의약 DB | ||||
[무작위배정 비교임상연구] J Evid Based Med. 2022
Qingjin Yiqi granules for post-COVID-19 condition: A randomized clinical trial.
....
본 임상시험의 처방인 청금익기과립 (QJYQ)은 인삼, 맥문동, 오미자, 반하, 현삼, 창출, 진피, 감초, 시호, 승마, 의이인, 황금, 마편초, 노근, 담죽엽 등 16종의 약재로 구성되어 있으며 중국의 허베이와 티엔진 지역...
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[무작위배정 비교임상연구] Climacteric. 2016
A randomized, double-blind, placebo-controlled trial of Schisandra chinensis for menopausal symptoms.
...].
영양 요법으로 콩에서 추출한 isoflavones은 갱년기 증상 개선에 효과가 있다고 보고되었고 [12]. 한약재 중 승마가 갱년기 증상과 관련하여 효과가 있다고 연구되었다 [12]. 그리고 오미자는 Alzheimer's disease와 혈관 질환에...
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약물상호작용 DB | ||||
[한약-양약 상호작용]
The estrogenic activity of black cohosh remains debated. Specific estrogenic constituents have not been identified, and it is unclear how (or if) black cohosh interacts with estrogens, estrogen receptors, and/or progesti
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... 발정기의 정상보다 이른 시작을 촉발시키지 않았다 [27]. 질 상피에 미치는 에스트로겐 효능이 3개월간의 승마 실험에서 기록되었으나 [28], 반면 6개월간의 연구에서는 질의 세포학에 미치는 효능이 보고되지 않았다 [29]....
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[한약-양약 상호작용]
Unlike that observed for rifampin and clarithromycin, midazolam pharmacokinetics was unaffected by black cohosh, and black cohosh did not appear to have a clinically relevant effect on CYP2D6 or CYP3A activity in vivo [
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... 배당체가 약하게 활동하는 것이 보고되었다(IC50: 25-100mcM). 그에 더하여, Hep-G2 세포 성장은 어떤 승마 추출물(50mcg/mL 만큼 높은 농도에서의 cimcifugic acids A와 B, 푸키놀릭산(fukinolic acid), 트리테르펜 배당체(triterpene...
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전체보기 지식솔루션센터 (5)건 |
생활 속 한의 |
세계 속의 의료인 |
학회/학술 일정 |
[센터]
약리작용 등록-승마49 연교43 의이인72 지골피9 (173개) |
[센터]
생약 저자키워드 검색-승마 연교 의이인 창출 |
근거중심한의약 DB |
[무작위배정 비교임상연구] J Evid Based Med. 2022
Qingjin Yiqi granules for post-COVID-19 condition: A randomized clinical trial.
....
본 임상시험의 처방인 청금익기과립 (QJYQ)은 인삼, 맥문동, 오미자, 반하, 현삼, 창출, 진피, 감초, 시호, 승마, 의이인, 황금, 마편초, 노근, 담죽엽 등 16종의 약재로 구성되어 있으며 중국의 허베이와 티엔진 지역...
|
[무작위배정 비교임상연구] Climacteric. 2016
A randomized, double-blind, placebo-controlled trial of Schisandra chinensis for menopausal symptoms.
...].
영양 요법으로 콩에서 추출한 isoflavones은 갱년기 증상 개선에 효과가 있다고 보고되었고 [12]. 한약재 중 승마가 갱년기 증상과 관련하여 효과가 있다고 연구되었다 [12]. 그리고 오미자는 Alzheimer's disease와 혈관 질환에...
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약물상호작용 DB | ||||
[한약-양약 상호작용]
The estrogenic activity of black cohosh remains debated. Specific estrogenic constituents have not been identified, and it is unclear how (or if) black cohosh interacts with estrogens, estrogen receptors, and/or progestins. Studies suggest that there may be no direct effects on estrogen receptors, although this is an area of active controversy [10;8;11;9;12;13;14;15]. Therefore, caution is warranted in individuals taking both black cohosh and estrogens, due to unknown effects, and interactions data in this area are lacking. In animals and in vitro, initial reports of estrogen receptor-binding activity [16] stand in contrast with data suggesting no significant estrogen receptor-binding activity or estrogenic activities [17;18;19;20]. One in vitro study found no effects of black cohosh alone on estrogen receptors, but it reported that black cohosh antagonized proliferative effects on cells induced by estradiol [21]. Several studies have aimed to assess estrogenic activity by measuring luteinizing hormone (LH), follicle-stimulating hormone (FSH), or prolactin levels [22;23]. One study reported lower FSH levels (but not LH) in patients treated with black cohosh vs. placebo (N=110), although baseline hormone levels were not known in either group [22]. Results from other trials have found no effects on these hormone levels after up to six months of black cohosh therapy [24;25;26]. When administered to female infantile mice, black cohosh could not precipitate the premature onset of estrus [27]. Estrogenic effects on vaginal epithelium were noted in one three-month trial of black cohosh [28], while a six-month trial reported no effects on vaginal cytology [29]. In a systematic review, with relevance to cancer patients, black cohosh also seemed to lack phytoestrogenic activity and may inhibit tumor growth [30].
... 발정기의 정상보다 이른 시작을 촉발시키지 않았다 [27]. 질 상피에 미치는 에스트로겐 효능이 3개월간의 승마 실험에서 기록되었으나 [28], 반면 6개월간의 연구에서는 질의 세포학에 미치는 효능이 보고되지 않았다 [29]....
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[한약-양약 상호작용]
Unlike that observed for rifampin and clarithromycin, midazolam pharmacokinetics was unaffected by black cohosh, and black cohosh did not appear to have a clinically relevant effect on CYP2D6 or CYP3A activity in vivo [43;44]. In a systematic review, the authors indicated that the effect of black cohosh on human cytochrome activity may be small [2]. However, another systematic review suggested that laboratory studies have shown that black cohosh may interact with CYP3A4 [45]. In a clinical trial of 16 healthy volunteers, supplementation of black cohosh for 14 days did not demonstrate an effect on CYP2D6 [46]. In vitro, strong inhibition of all CYP isoenzymes was documented due to cimicifugic acids A and B and fukinolic acid at median inhibitory concentrations (IC50) of 1.8-12.6mcM [47;48]. Triterpene glycosides were reported to be weakly active (IC50: 25-100mcM). In addition, Hep-G2 cell growth was not shown to be inhibited by any black cohosh extracts (cimicifugic acids A and B, fukinolic acid, and triterpene glycosides in concentrations as high as 50mcg/mL) [47]. However, in vitro, seven black cohosh products were not shown to inhibit CYP3A4 in the human liver [49]. In vitro, methanolic extracts of black cohosh were shown to inhibit CYP2B6, (5)2C19, and (D)2C19 in human liver cells [50]. In vitro, black cohosh has been reported to lack an effect on CYP450-catalyzed 4-hydroxylation of estradiol in human mammary epithelial cells [51]. In mice, black cohosh at a dose of 500mg/kg was reported to induce liver CYP3A11 sevenfold after 28 days of treatment [48;52]. This induction was reported to be both time- and dose-dependent. A change in the kidney and small intestine CYP3A11was lacking. In further research, mouse pregnane X receptor (PXR) was reported to be activated by black cohosh, but human PXR was not [52]. In a case report, black cohosh has been reported to interact with atorvastatin, resulting in an increase in liver enzymes, possibly due to inhibition of CYP3A4 [35].
... 배당체가 약하게 활동하는 것이 보고되었다(IC50: 25-100mcM). 그에 더하여, Hep-G2 세포 성장은 어떤 승마 추출물(50mcg/mL 만큼 높은 농도에서의 cimcifugic acids A와 B, 푸키놀릭산(fukinolic acid), 트리테르펜 배당체(triterpene...
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