KMCRIC

1.
[Interaction]
In HeLa cervical cancer cells, pre-treatment with a low dose of Hochu-ekki-to (HET, 50 ug/mL for 24 h) - which alone did not affect cell viability - enhanced cisplatin-induced apoptosis. Flow cytometry showed a distinct increase in the sub-G1 population. Mechanistically, HET down-regulated p-Akt and the Bcl-2/Bax ratio, and stimulated cisplatin-induced up-regulation of p53 and active caspase-3 [​3​].

[Expert interpretation]
Bojungikgi-tang enhances Cisplatin-induced apoptosis through down-regulation of p-Akt and the Bcl-2/Bax ratio and up-regulation of p53/caspase-3, thereby increasing the Cisplatin sensitivity of cervical cancer cells.

2.
[Interaction]
In cisplatin-resistant lung cancer A549/DDP cells, Bu-Zhong-Yi-Qi decoction (BZYQD) showed direct cytotoxic and chemosensitizing effects. Cotreatment with BZYQD and cisplatin induced the intrinsic apoptotic pathway and also activated autophagy, as indicated by increased LC3 puncta and accumulation of LC3-II and ATG7 protein [​4​].

[Expert interpretation]
Bojungikgi-tang potentiates Cisplatin cytotoxicity through induction of intrinsic apoptosis and autophagy, thereby contributing to the reversal of Cisplatin resistance.

...
[한약투여조건]
Material: Hochu-ekki-to (HET, TJ-41) - 10종 약재 구성 Kampo 제제
구성: 황기, 감초, 당삼 (인삼), 당귀, 진피, 승마, 시호, 백출
Treatment: 50 μg/mL (단독으로는 세포 생존율에 영향 없는 저농도). 24시간 전처리 후 Cisplatin...

1.
[Interaction]
In male SD rats given a single oral dose of ondansetron (10 mg/kg) with Ijintang-gamibang (IJTGMB, 100 mg/kg) co-administered orally within 5 min, the plasma concentration profile of ondansetron did not differ from the control, and none of the pharmacokinetic parameters (Tmax, Cmax, AUC, t1/2, MRTinf) differed between the two treatments. The same was true for the initial dose of the repeated-dosing study after 6 days of IJTGMB pretreatment [​2​].

[Expert interpretation]
Ijintang-gamibang does not affect the pharmacokinetics of Ondansetron on single co-administration, as it alters neither the absorption nor the elimination of Ondansetron, with or without 6-day pretreatment.

2.
[Interaction]
After 8 days of repeated co-administration (following 6 days of IJTGMB pretreatment), plasma ondansetron was detected at lower concentrations and for a longer duration in the combination group than in the control. AUC0-t decreased from 460.82 +- 150.84 to 281.15 +- 60.21 ng*h/mL and AUC0-inf from 473.32 +- 164.17 to 291.54 +- 59.10 ng*h/mL (both p<0.05); Cmax fell from 327.60 +- 57.35 to 237.60 +- 72.96 ng/mL, while t1/2 (0.66 -> 0.78 h) and MRTinf (1.35 -> 1.33 h) were largely unchanged [​2​].

[Expert interpretation]
Repeated co-administration of Ijintang-gamibang significantly reduces the bioavailability of Ondansetron by interfering with its absorption while leaving t1/2 and MRTinf unchanged; the authors suggest separating the two by an interval longer than the MRTinf of Ondansetron.

... 유무와도 무관함.

[한약투여조건]
Material: Omni Herb(영천) 약재로 제조한 물 추출물 (동결 건조)
구성: 반하 16, 진피 8, 복령 8, 창출 8, 신곡 8, 맥아 8, 황련 8, 감초 4 (총 68 g)
* 이진탕 (반하·진피·복령·감초)에...

Water and ethyl acetate extracts of Citrus unshiu peel inhibited hepatitis C virus infection in MOLT-4 cells.

진피 (Citrus unshiu)의 물과 에틸아세테이트 추출물은 MOLT-4 세포의 C형 간염 바이러스 감염을 억제함.

Aqueous extraction of Citrus unshiu peel induces proangiogenic effects via the FAK and ERK1/2 signaling pathway in Human Umbilical Vein Endothelial Cells.

진피 (Citrus unshiu) 물 추출물은 사람 태아정맥 내피세포에서 FAK, ERK1/2 신호경로를 통해 혈관신생을 유도함.