KMCRIC

1.
[Interaction]
When Gamisoyosan and Tamoxifen were administered in mouse models implanted with breast cancer cell line MCF-7, Tamoxifen's inhibitory effect on cancer cell growth and autophagy signaling was maintained [​3​].

[Expert interpretation]
Gamisoyosan does not affect the anticancer efficacy of Tamoxifen.

2.
[Interaction]
When Gamisoyosan and Tamoxifen were treated in breast cancer cell line MCF-7, Tamoxifen's cytotoxicity and efficacy on autophagy signaling were maintained [​3​].

[Expert interpretation]
Gamisoyosan does not affect the anticancer efficacy of Tamoxifen.

3.
[Interaction]
When administered to a normal rat model with gamisoyosan and tamoxifen, gamisoyosan did not affect the plasma absorption rate (AUC, Cmax, Tmax) or half-life (T1/2) of tamoxifen [​4​].

[Expert interpretation]
Gamisoyosan did not affect the blood concentration of tamoxifen.

... MCF-7에 가미소요산과 타목시펜 처리 시, Tamoxifen의 세포 독성 및 자가포식 신호에 대한 효능이 유지되었음 [​3​].

... Tamoxifen의 항암 효능에 영향을 주지 않음.

[한약투여조건]
Material: Sun Ten Pharmaceutical Co, Ltd. (물...

In animal study, schisandra or its constituents had neurological effects, including improving amnesia and exerting inhibitory effects on the central nervous system [​56​;​38​]. Schisandra extracts enhanced the passive-avoidance response in tacrine-treated animals [​57​]. In tert-butylhydroperoxide-treated animals, schisandrin B reduced cerebral toxicity and lipid peroxidation [​58​]. In vitro, a methanolic acid extract of dried schisandra fruit attenuated glutamate-induced neurotoxicity [​59​]. In animal study, a combination herbal product containing Schisandra chinensis improved cognitive deficiency following sleep reduction; it also increased spontaneous activity, antagonized the inhabitation induced by diazepam (Valium®), and shortened the sleeping time caused by sodium pentobarbital [​60​].

... 치료한 동물에서, 스키산드린 B (schisandrin B)는 뇌 독성과 지질 과산화를 감소시켰다 [​58​]. 시험관 내... 유발된 신경 독성을 약화시켰다 [​59​]. 동물 연구에서, 오미자를 함유한 한약 처방 제품은 수면...