KMCRIC

Clinical research has examined the effect of chromium on obesity and weight loss [​55​;​56​;​57​;​58​;​59​;​60​;​61​;​62​;​63​;​64​;​65​;​66​;​67​]. According to a meta-analyses of human research, treatment with chromium supplementation was associated with a 1.1-1.2kg decrease in body weight vs. placebo in participants with an average body mass index of 28-33kg/m2 [​68​;​69​;​49​]. In a clinical trial, females taking chromium picolinate had a significant weight increase vs. males and placebo, while males increased in the sum of body circumferences and decreased in the sum of skinfolds compared to baseline [​58​].

... 1.1-1.2kg의 체중 감량의 효과가 있었다 [​68​;​69​;​49​]. 임상 시험에서, 크로뮴 피콜리네이트를 복용한 여성들은 남성들이 기초 대비 신체둘레 총합이 증가했고, 피부 두겹의 총합이 감소했던 것과 다르게 플라시보 및 남성...

In animal and human models, omega-3 fatty acids lowered triglyceride levels [​63​;​64​;123;​96​;​97​;​67​;​98​;​99​] and increased HDL cholesterol levels [​63​;​64​;123;​67​]; they may increase (worsen), decrease (improve), or have no effect on low-density lipoprotein (LDL; "bad") cholesterol levels [​63​;123;​97​;​67​]. In human research, addition of omega-3 fatty acids to simvastatin increased LDL cholesterol levels; however, this increase was confined predominantly to those with low LDL cholesterol levels [​100​]. In patients with metabolic syndrome, purified EPA decreased small, dense LDL cholesterol and remnant lipoprotein particles [​217​]. In hypertriglyceridemic men, DHA decreased levels of triglyceride and small, dense LDL particles [​238​]. In healthy men, fish oil in a single meal increased very-low-density lipoprotein (VLDL) concentration but reduced VLDL particle size vs. a reference meal [​239​]. In healthy Japanese subjects with a high basal level of fish consumption, fish oil supplementation did not decrease plasma triglyceride, total cholesterol, LDL cholesterol, or whole-blood viscosity, and there were no changes in the fatty acid composition of plasma and erythrocyte phospholipids [​240​]. In children with hyperlipidemia following a low-fat diet, DHA increased LDL subclass 1 and HDL subclass 2 (large and buoyant; less atherogenic particles) and decreased LDL subclass 3 (small and dense; more atherogenic particles) [​241​]. In hypertriglyceridemic men, DHA decreased fasting plasma remnant-like particle-cholesterol (RLP-C) and improved the red blood cell omega-3 index, novel risk factors for cardiovascular disease [​242​]. In type 2 diabetic patients, treatment with n-3 LC-PUFAs decreased the particle size of VLDL and increased the particle size of HDL [​243​].

... [​217​]. 고중성지방혈증 남성에게서, DHA은 트리슬리세리드와 작고 조밀한 지단백 입자를 감소시켰다 [​238​]. 건강한 남성에서, 한끼 식사에 들어가 있는 어유(油)는 초저밀도 지단백(VLDL) 농도를 증가시켰으나, 권장 식사와...

Treatment with schaftoside from Rhizoma Arisaematis in α-MSH-treated cells reduces the expression of tyrosinase and TRP1, and activates autophagy, suggesting that schaftoside in RA regulates melanogenesis by affecting the biogenesis of melanin as well as degrading synthesized melanin.

천남성으로부터 분리된 schaftoside는 α-MSH 처리된 쥐 흑색종 세포 B16F1 세포에서 멜라닌 생성 증가를 억제하고 tyrosinase와 TRP1 단백질의 발현을 하향 조절하여 자가포식 활성화를 통해 멜라닌 생성 억제 효과를 보임.

Apolar extracts from processed rhizomes of Arisaema sp. In HEK 293 cells effectively inhibited TNF-α-induced NF-κB activation and dose-dependently activated PPARα and PPARγ.

천남성 유래 벤진 및 다이클로로메테인 추출물은 사람 태아 신장 세포 HEK 293 세포에서 PPARα와 PPARγ를 용량 의존적으로 활성화하고 특히 벤진 추추물은 TNF-α로 유발된 NF-κB를 억제하는 효과를 보임.